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免疫功能正常的原发性喉曲霉菌病患者合并肺结核。

Pulmonary tuberculosis in an immunocompetent patient with primary laryngeal aspergillosis.

作者信息

Sarkar Nirmal Kanti, Gope Bijoy Pada

机构信息

Department of Respiratory Medicine Mugda Medical College Dhaka Bangladesh.

Department of Respiratory Medicine M.A.G. Osmani Medical College Sylhet Bangladesh.

出版信息

Respirol Case Rep. 2020 May 17;8(5):e00586. doi: 10.1002/rcr2.586. eCollection 2020 Jul.

DOI:10.1002/rcr2.586
PMID:32431816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7231804/
Abstract

Primary laryngeal aspergillosis in an immunocompetent host is a rare entity. On the other hand, pulmonary tuberculosis (PTB) among healthcare workers in a tuberculosis endemic zone with high risk of exposure is not uncommon but may be underdiagnosed especially when masquerading as another disease. In this report, we are presenting a 45-year-old physician who presented with chronic dry cough, hoarseness of voice, and progressive vocal fatigue. Fibreoptic laryngoscopy (FOL) showed whitish patches on both vocal folds and he was initially diagnosed with laryngeal aspergillosis following histopathological examination. As there was no significant improvement on antifungal treatment, we re-evaluated the case and, on further investigation, concomitant PTB was detected. Patient responded to category-I anti-tubercular drugs with complete recovery.

摘要

免疫功能正常宿主的原发性喉曲霉菌病是一种罕见的病症。另一方面,在结核病流行且接触风险高的地区,医护人员患肺结核(PTB)并不罕见,但可能诊断不足,尤其是当它伪装成另一种疾病时。在本报告中,我们介绍了一位45岁的医生,他出现慢性干咳、声音嘶哑和进行性声音疲劳。纤维喉镜检查(FOL)显示双侧声带均有白色斑块,经组织病理学检查后,他最初被诊断为喉曲霉菌病。由于抗真菌治疗后无明显改善,我们重新评估了该病例,进一步检查后发现合并有PTB。患者对I类抗结核药物有反应并完全康复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d05/7231804/64ff63e1892b/RCR2-8-e00586-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d05/7231804/a0e6cd0d535b/RCR2-8-e00586-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d05/7231804/4a99db040b4f/RCR2-8-e00586-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d05/7231804/64ff63e1892b/RCR2-8-e00586-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d05/7231804/a0e6cd0d535b/RCR2-8-e00586-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d05/7231804/4a99db040b4f/RCR2-8-e00586-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d05/7231804/64ff63e1892b/RCR2-8-e00586-g003.jpg

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本文引用的文献

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Primary invasive laryngeal mycosis in an immunocompetent patient: a case report and clinico-epidemiological update.免疫功能正常患者原发性侵袭性喉真菌病 1 例报告及临床流行病学更新。
BMC Infect Dis. 2018 Jul 11;18(1):323. doi: 10.1186/s12879-018-3219-1.
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Risk of Tuberculosis Infection and Disease for Health Care Workers: An Updated Meta-Analysis.医护人员感染结核病和患结核病的风险:一项更新的荟萃分析。
Open Forum Infect Dis. 2017 Aug 29;4(3):ofx137. doi: 10.1093/ofid/ofx137. eCollection 2017 Summer.
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