Bassalyk L S, Kushlinskiĭ N E, Revazova E S, Degtiar' V G
Eksp Onkol. 1988;10(6):29-31.
Intraperitoneal testosterone administration stimulated the growth of subcutaneously transplanted cell line of human osteogenic sarcoma in nude rats but did not provoke tumour metastasizing to other organs and tissues. The specific connection of androgens with receptor proteins in the cytosol fraction was not found in the studied osteogenic sarcomas, whereas cytoplasmic estrogen receptors were revealed in all tumours. It is supposed that the mechanism of the stimulating effect of androgens on the tumour growth is mediated through other biologic systems being not related to androgen receptors.
腹腔内注射睾酮可刺激人骨肉瘤皮下移植细胞系在裸鼠体内生长，但不会引发肿瘤转移至其他器官和组织。在所研究的骨肉瘤中未发现雄激素与胞质溶胶部分受体蛋白的特异性结合，而在所有肿瘤中均检测到了细胞质雌激素受体。据推测，雄激素对肿瘤生长的刺激作用机制是通过与雄激素受体无关的其他生物系统介导的。
