用于疾病建模的血管微生理系统
Vascular Microphysiological Systems to Model Diseases.
作者信息
Zhang Qiao, Zhang Xu, Truskey George A
机构信息
Department of Biomedical Engineering, Duke University, 1427 CIEMAS, 101 Science Drive, Durham, NC 27708-0281, USA.
出版信息
Cell Gene Ther Insights. 2020;6(1):93-102. doi: 10.18609/cgti.2020.012. Epub 2020 Feb 14.
Abstract
Human vascular microphysiological systems (MPS) represent promising three-dimensional models of normal and diseased vascular tissue. These systems build upon advances in tissue engineering, microfluidics, and stem cell differentiation and replicate key functional units of organs and tissues. Vascular models have been developed for the microvasculature as well as medium-size arterioles. Key functions of the vascular system have been reproduced and stem cells offer the potential to model genetic diseases and population variation in genes that may increase individual risk for cardiovascular disease. Such systems can be used to evaluate new therapeutics options.
摘要
人类血管微生理系统（MPS）是正常和患病血管组织很有前景的三维模型。这些系统基于组织工程、微流体技术和干细胞分化的进展构建而成，可复制器官和组织的关键功能单元。已开发出针对微脉管系统以及中尺寸小动脉的血管模型。血管系统的关键功能已得到再现，并且干细胞为模拟遗传疾病以及可能增加个体心血管疾病风险的基因中的群体变异提供了潜力。此类系统可用于评估新的治疗方案。
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