Harrington Deborah L, Jahanshahi Marjan
Research Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.
Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA.
Curr Opin Behav Sci. 2016 Apr;8:78-84. doi: 10.1016/j.cobeha.2016.02.007.
The medial cortico-striatal-thalamo-cortical (CSTC) motor circuit is a core system that exerts control over interval timing and action. A common network generates these behaviors possibly owing to cellular coding of temporal and non-temporal information, which in turn promotes reconfiguration of functional connectivity in accord with behavioral goals. At the neuroanatomical level, support for flexible CSTC reconfiguration comes from studies of temporal illusions demonstrating that this system calibrates the experience of time through functional interactions with various context-sensitive brain regions. Revelations that CSTC effective connectivity is pivotal for context-dependent facets of voluntary actions, namely action planning, complement its role in predictive processes such as timing. These observations suggest that the CSTC is positioned to represent high-level information about 'what to do' and 'when to do it' by dynamically reconfiguring effective connectivity as circumstances arise.
内侧皮质-纹状体-丘脑-皮质（CSTC）运动回路是一个对间隔计时和动作施加控制的核心系统。一个共同的网络可能由于时间和非时间信息的细胞编码而产生这些行为，这反过来又促进了功能连接根据行为目标进行重新配置。在神经解剖学层面，对CSTC灵活重新配置的支持来自于时间错觉研究，这些研究表明该系统通过与各种上下文敏感脑区的功能相互作用来校准时间体验。CSTC有效连接对于自愿动作的上下文相关方面（即动作规划）至关重要，这一发现补充了其在诸如计时等预测过程中的作用。这些观察结果表明，CSTC能够通过在情况出现时动态重新配置有效连接来表征有关“做什么”和“何时做”的高级信息。
