Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
AstraZeneca UK Ltd, 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0FZ, UK.
Chem Commun (Camb). 2020 Jun 23;56(50):6818-6821. doi: 10.1039/d0cc02728f.
Herein, we describe the development of a simple, high yielding and stereocontrolled strategy for the synthesis of a series of triazolopiperazines and other biologically relevant fused scaffolds from optically active amino acids. This route was applied to the synthesis of 22 scaffolds containing new, previously inaccessible vectors and used to access a novel analogue of ganaplacide.
在此，我们描述了一种从光学活性氨基酸合成一系列三唑并哌嗪和其他生物相关稠合支架的简单、高产和立体控制策略。该路线应用于合成 22 个含有新的、以前无法获得的载体的支架，并用于合成 ganaplacide 的一种新型类似物。
