Institute for Health Care Science, Suntory Wellness Limited, Kyoto, Japan.
Eur Rev Med Pharmacol Sci. 2020 May;24(9):5140-5147. doi: 10.26355/eurrev_202005_21208.
Sesamin is a functional ingredient in sesame (Sesamum indicum) seeds and has many physiological effects. This study investigated whether sesame lignans, sesamin and episesamin (1:1), can suppress age-related disorders of the kidney.
Twenty-month-old mice were divided into three groups, and each group received a regular diet (O-C), diet containing sesame lignans (O-SE), and diet containing sesame lignans and α-tocopherol (VE; O-SE+VE), respectively, for 5 months. Six-month-old young mice (Y-C) were compared to the older mice.
Renal lipofuscin deposition was increased in the O-C group compared to that in the Y-C group and its deposition with aging was significantly decreased in both O-SE and O-SE+VE groups. Plasma blood urea nitrogen levels in the O-C group increased compared to those in the Y-C group; however, those in both O-SE and O-SE+VE groups did not differ from those in the Y-C group. The number of podocytes in the O-C group decreased compared to that in the Y-C group and this effect was attenuated in the O-SE and O-SE+VE groups. The effect was strongest in the O-SE+VE group. Histological examinations showed that glomerular hypertrophy accompanied by mesangial hyperplasia and renal tubular degeneration was less severe in the O-SE and O-SE+VE groups than in the O-C group. Moreover, age-related increases in the mRNA expression of NADPH oxidase- and inflammation-related genes, including p67phox, p40phox, TNFα, and IL-6, in the kidney were suppressed in the O-SE and O-SE+VE groups.
Sesame lignans might be useful to suppress age-related kidney disorders, and these effects could be enhanced with VE.
芝麻素是芝麻（Sesamum indicum）种子中的一种功能性成分，具有许多生理作用。本研究旨在探讨芝麻木脂素（sesamin 和 episesamin，比例为 1:1）是否可以抑制与年龄相关的肾脏疾病。
将 20 月龄的小鼠分为三组，分别给予普通饮食（O-C）、含芝麻木脂素的饮食（O-SE）和含芝麻木脂素和α-生育酚（VE；O-SE+VE）的饮食，连续喂养 5 个月。将 6 月龄的年轻小鼠（Y-C）与老年小鼠进行比较。
与 Y-C 组相比，O-C 组肾脏脂褐素沉积增加，且随年龄增长其沉积显著减少，O-SE 和 O-SE+VE 组也有类似趋势。与 Y-C 组相比，O-C 组血浆血尿素氮水平升高，但 O-SE 和 O-SE+VE 组与 Y-C 组无差异。与 Y-C 组相比，O-C 组足细胞数量减少，而 O-SE 和 O-SE+VE 组可减轻这一变化，其中 O-SE+VE 组效果最强。组织学检查显示，与 O-C 组相比，O-SE 和 O-SE+VE 组肾小球肥大伴系膜增生和肾小管变性较轻。此外，O-SE 和 O-SE+VE 组还可抑制肾脏 NADPH 氧化酶和炎症相关基因（包括 p67phox、p40phox、TNFα 和 IL-6）的表达随年龄增长而增加。
芝麻木脂素可能有助于抑制与年龄相关的肾脏疾病，且与 VE 联合使用效果更佳。
