Institute for Health Care Science, Suntory Wellness Limited, Kyoto 619-0284, Japan.
Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Nutrients. 2019 Jul 12;11(7):1582. doi: 10.3390/nu11071582.
Sesame lignans, which are biologically active compounds present in sesame seeds and oil, are known to have neuroprotective effects in several models of brain dysfunction. However, the effects of sesame lignans on age-related brain dysfunction are not clear and were thus investigated in the present study using a senescence-accelerated mouse (SAMP10). Two-month-old male SAMP10 mice were administrated a basal diet with 0% or 0.05% sesame lignans for two months, or with 0%, 0.02%, or 0.05% sesame lignans for 10 months and subjected to step-through passive avoidance tasks and forced swim tests. Reactive carbonyl species (RCs) were evaluated as markers of oxidative stress using a recently developed comprehensive analytical method. Both learning time in passive avoidance tasks and immobile time in forced swim tests became longer with aging ( < 0.05). However, the administration of sesame lignans significantly ameliorated age-related effects in both tests ( < 0.05). Age-related increases in RCs such as 4-hydroxy-2-nonenal in the cerebral cortex and liver were reduced in mice fed sesame lignans. These results suggest that sesame lignans can prevent age-related brain dysfunction via anti-oxidative activity.
芝麻木脂素是存在于芝麻种子和油中的具有生物活性的化合物，已知对几种脑功能障碍模型具有神经保护作用。然而，芝麻木脂素对与年龄相关的脑功能障碍的影响尚不清楚，因此本研究使用衰老加速小鼠（SAMP10）进行了研究。将 2 月龄雄性 SAMP10 小鼠用含 0%或 0.05%芝麻木脂素的基础饲料喂养 2 个月，或用 0%、0.02%或 0.05%芝麻木脂素喂养 10 个月，并进行避暗式被动回避任务和强迫游泳试验。使用最近开发的综合分析方法，将反应性羰基物质（RCs）作为氧化应激的标志物进行评估。被动回避任务中的学习时间和强迫游泳试验中的不动时间随着年龄的增长而延长（<0.05）。然而，芝麻木脂素的给药显著改善了两种试验中的与年龄相关的作用（<0.05）。在大脑皮层和肝脏中，与年龄相关的 RCs（如 4-羟基-2-壬烯醛）的增加在喂食芝麻木脂素的小鼠中减少。这些结果表明，芝麻木脂素可以通过抗氧化活性预防与年龄相关的脑功能障碍。
