Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan.
Org Lett. 2020 Jun 5;22(11):4467-4470. doi: 10.1021/acs.orglett.0c01464. Epub 2020 May 20.
Herein reported is a dehydrative coupling reaction of alkyl amines with allylic alcohols promoted by co-operation of photoredox and palladium catalysts. A range of homoallylic amines are efficiently synthesized. A mechanistic study suggests that an in situ generated carboxylic acid activates an allylic alcohol to facilitate its oxidative addition onto palladium.
本文报道了光氧化还原和钯催化剂协同作用促进的烷基胺与烯丙醇的脱水偶联反应。一系列偕胺类化合物被高效合成。机理研究表明，原位生成的羧酸激活烯丙醇，促进其氧化加成到钯上。
