Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Dr. Dalvin is now with the Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
Retina. 2021 Feb 1;41(2):259-265. doi: 10.1097/IAE.0000000000002855.
To determine the association between vitreoretinal lymphoma and systemic lymphoma (SL).
Single-center retrospective review of medical records.
Of 95 patients with vitreoretinal lymphoma, 18 (19%) had associated SL (SL group) and 77 (81%) were not associated with SL (no SL group). The most common sites of SL were skin (n = 5), testis (n = 2), liver and breast (n = 2), and others (n = 9). A comparison (SL group vs. [vs.] no SL group) revealed no difference in demographic or ocular findings at initial visit. In the SL group, SL occurred before the onset of ocular symptoms in 14 (78%) patients with mean interval of 86 months (median 61, range 5-286 months) or after ocular symptoms in 4 (22%) patients with mean interval of 19 months (median 12, range 7-44 months). A comparison revealed no difference in overall frequency of pre-existing or eventual central nervous SL (50% vs. 53%, P = 0.99); however, the SL group demonstrated central nervous SL more often after onset of ocular symptoms (78% vs. 17%, P = 0.001). A comparison found no difference in treatment methods, response of vitreoretinal lymphoma to treatment, final visual outcome, or death rate.
We found 19% of patients with vitreoretinal lymphoma demonstrate related SL, and there was no difference in demographics, clinical features, or response to treatment, compared to those not associated with SL.
确定眼内视网膜淋巴瘤与全身淋巴瘤（SL）之间的关联。
对单中心病历进行回顾性研究。
在 95 例眼内视网膜淋巴瘤患者中，有 18 例（19%）存在相关的 SL（SL 组），77 例（81%）与 SL 无关（无 SL 组）。SL 最常见的部位为皮肤（n = 5）、睾丸（n = 2）、肝脏和乳房（n = 2），以及其他部位（n = 9）。比较（SL 组与无 SL 组）发现，两组患者在初次就诊时的人口统计学或眼部表现无差异。在 SL 组中，14 例（78%）患者的 SL 发生在眼部症状出现之前，平均间隔时间为 86 个月（中位数为 61，范围为 5-286 个月），4 例（22%）患者的 SL 发生在眼部症状之后，平均间隔时间为 19 个月（中位数为 12，范围为 7-44 个月）。比较发现，两组患者预先存在或最终发生中枢性 SL 的频率无差异（50% vs. 53%，P = 0.99）；然而，SL 组在眼部症状出现后更常出现中枢性 SL（78% vs. 17%，P = 0.001）。比较发现，两组患者治疗方法、眼内视网膜淋巴瘤对治疗的反应、最终视力结果或死亡率均无差异。
我们发现，19%的眼内视网膜淋巴瘤患者存在相关的 SL，与不相关的 SL 患者相比，两组患者在人口统计学、临床特征或对治疗的反应方面均无差异。
