Carroccio A, Pardo F, Montalto G, Japichino L, Iacono G, Collura M, Notarbartolo A
Cattedra di Patologia Medica, Università di Palermo, Italia.
Digestion. 1988;41(4):201-6. doi: 10.1159/000199788.
To evaluate the effectiveness of enteric-coated pancreatic enzyme supplements in comparison to conventional preparations of ingested enzyme on growth and nutritional parameters of patients with cystic fibrosis, we conducted a long-term study involving 40 patients. The data reproduced here were recorded after 6 months of therapy with powder-containing capsules or with enteric-coated products. Fat absorption was estimated by measurement of steatorrhoea with the steatocrit method. All parameters studied improved after enteric-coated pancreatic enzyme therapy, with a statistically significant increase in weight, cholesterol and haemoglobin values. Furthermore, the number of patients with positive steatocrit test was lower after therapy with enteric-coated enzyme supplementation. These findings suggest that the enteric-coated product not only reduces steatorrhoea, but above all improves the nutritional parameters and growth of patients affected by cystic fibrosis.
为了评估肠溶包衣胰酶补充剂与传统摄入酶制剂相比，对囊性纤维化患者生长和营养参数的有效性，我们进行了一项涉及40名患者的长期研究。此处重现的数据是在使用含粉末胶囊或肠溶包衣产品治疗6个月后记录的。通过用脂肪比容法测量脂肪泻来估计脂肪吸收情况。在接受肠溶包衣胰酶治疗后，所有研究参数均有所改善，体重、胆固醇和血红蛋白值有统计学意义的增加。此外，接受肠溶包衣酶补充治疗后，脂肪比容试验呈阳性的患者数量减少。这些发现表明，肠溶包衣产品不仅能减少脂肪泻，而且最重要的是能改善囊性纤维化患者的营养参数和生长情况。
