在 40Hz 光闪烁环境中进行体育锻炼可改善阿尔茨海默病 3xTg 小鼠模型的认知功能。
Physical exercise during exposure to 40-Hz light flicker improves cognitive functions in the 3xTg mouse model of Alzheimer's disease.
机构信息
Department of Physiology, College of Medicine, KyungHee University, Seoul, Republic of Korea.
Department of Kinesiology, College of Public Health and Cardiovascular Research Center, Lewis Katz school of Medicine, Temple University, Philadelphia, PA, USA.
出版信息
Alzheimers Res Ther. 2020 May 20;12(1):62. doi: 10.1186/s13195-020-00631-4.
BACKGROUND
Exercise promotes brain health and improves cognitive functioning in the elderly, while 40-Hz light flickering through the visual cortex reduces amyloid beta (Aβ) by stabilizing gamma oscillation. We examined whether exercise was associated with hippocampus-mediated improvement in cognitive functioning in the 3xTg-Alzheimer's disease (3xTg-AD) murine model following exposure to 40-Hz light flickering and exercise.
METHODS
We subjected 12-month-old 3xTg-AD mice to exercise and 40-Hz light flickering for 3 months to investigate spatial learning, memory, long-term memory, Aβ levels, tau levels, mitochondrial functioning including Ca retention and HO emission, apoptosis, and neurogenesis in the hippocampus.
RESULTS
Treatments had a positive effect; however, the combination of exercise and 40-Hz light flickering exposure was most effective in reducing Aβ and tau levels. Reducing Aβ and tau levels by combination of exercise and 40-Hz light flickering improves Ca homeostasis and reactive oxygen species such as HO in mitochondria and apoptosis including bax, bcl-2, cytochrome c, and cleaved caspase-3 and cell death, cell differentiation, and neurogenesis in the 3xTg-AD model of the hippocampus, resulting in improving cognitive impairment such as spatial learning, memory and long term memory.
CONCLUSION
Our results show that exercising in a 40-Hz light flickering environment may improve cognitive functioning by reducing Aβ and tau levels, thereby enhancing mitochondrial function and neuroplasticity.
背景
运动可促进大脑健康并改善老年人的认知功能，而 40Hz 光闪烁通过视觉皮层可通过稳定伽马振荡来减少淀粉样蛋白β（Aβ）。我们研究了在暴露于 40Hz 光闪烁和运动后，运动是否与海马介导的 3xTg-阿尔茨海默病（3xTg-AD）小鼠模型中的认知功能改善有关。
方法
我们使 12 个月大的 3xTg-AD 小鼠接受运动和 40Hz 光闪烁治疗 3 个月，以研究空间学习、记忆、长期记忆、Aβ水平、tau 水平、海马体中的线粒体功能（包括 Ca 保留和 HO 发射）、细胞凋亡和神经发生。
结果
治疗有积极作用；但是，运动和 40Hz 光闪烁暴露的组合在降低 Aβ和 tau 水平方面最有效。通过运动和 40Hz 光闪烁的组合降低 Aβ和 tau 水平可改善 Ca 稳态和活性氧（如线粒体中的 HO）以及细胞凋亡，包括 bax、bcl-2、细胞色素 c 和裂解的 caspase-3 和细胞死亡、细胞分化和海马体中的神经发生，从而改善认知障碍，如空间学习、记忆和长期记忆。
结论
我们的结果表明，在 40Hz 光闪烁环境中运动可以通过降低 Aβ和 tau 水平来改善认知功能，从而增强线粒体功能和神经可塑性。
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