Almeanazel Osaid, Alanazi Fars, Alsarra Ibrahim, Alshora Doaa, Shakeel Faiyaz, Almnaizel Ahmad, Alahmed Mohammed, Fouad Ehab
Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, King Saud University, Riyadh, Saudi Arabia.
Prince Naif for Health Research Center, King Saud University, Riyadh, Saudi Arabia.
Saudi Pharm J. 2020 May;28(5):565-573. doi: 10.1016/j.jsps.2020.03.008. Epub 2020 Mar 19.
Obesity is a metabolic disease that affects all ages; it is considered life-threatening condition as it leads to fatal complications such as; cardiovascular diseases and diabetes. The therapeutic options include; life-style modifications, pharmacotherapy intervention, and surgical intervention. Bariatric surgery (BS) is considered as the most effective option among the others for its rapid weight loss, maintaining the lost mass, and improving the quality of life of the patients. Nevertheless, BS leads to severe changes in the bioavailability of medications, especially for chronic diseases, which may reach to limit where the patient's life endangers. Recently, pharmaceutical formulations had developed several methods to improve the drug bioavailability of drugs though the implying of nanotechnology. Nonotechnology is responsible for reducing the size of the drugs to the nano range (<1000 nm), which increase the drug surface area, dissolution, absorption, and, most importantly, the bioavailability of these drugs. It is believed that BS malabsorption and drugs bioavailability problems can be solved using nanotechnology for its advantages in overcoming BS complications.
肥胖是一种影响所有年龄段的代谢性疾病；它被认为是一种危及生命的状况，因为它会导致致命的并发症，如心血管疾病和糖尿病。治疗选择包括生活方式改变、药物治疗干预和手术干预。减重手术（BS）因其能快速减重、维持减重效果并改善患者生活质量，被认为是其他治疗方法中最有效的选择。然而，减重手术会导致药物生物利用度发生严重变化，尤其是对于慢性病，这可能会达到危及患者生命的程度。最近，药物制剂通过应用纳米技术开发了几种提高药物生物利用度的方法。纳米技术负责将药物尺寸减小到纳米范围（<1000纳米），这增加了药物的表面积、溶解度、吸收率，最重要的是，提高了这些药物的生物利用度。人们认为，利用纳米技术在克服减重手术并发症方面的优势，可以解决减重手术的吸收不良和药物生物利用度问题。
