阿拉巴马州黑人的囊性纤维化DNA标记
Cystic fibrosis DNA markers in Alabama blacks.
作者信息
Martin R K, Kaplan G C, Hodge T W, Barker P E
机构信息
Laboratory of Medical Genetics, University of Alabama, Birmingham 35294.
出版信息
Genomics. 1988 Nov;3(4):385-8. doi: 10.1016/0888-7543(88)90132-2.
DNA samples from unrelated Alabama blacks with no family history of cystic fibrosis (CF) were analyzed with DNA markers linked to cf. Allelic frequencies of genetic markers detected by probes pmetH, pmetD, XV2c, KM19, and pJ3.11 were compared to those of other populations. Allelic frequencies for pJ3.11, XV2c, and KM19 in Alabama blacks and previously studied Caucasian populations were similar. In contrast, the met locus allelic frequencies in Alabama blacks were markedly different from those in Caucasian populations.
对来自阿拉巴马州、无囊性纤维化（CF）家族病史的非亲属黑人的DNA样本，使用与CF相关的DNA标记进行分析。将探针pmetH、pmetD、XV2c、KM19和pJ3.11检测到的遗传标记的等位基因频率与其他人群的进行比较。阿拉巴马州黑人中pJ3.11、XV2c和KM19的等位基因频率与之前研究的白种人群体相似。相比之下，阿拉巴马州黑人中met位点的等位基因频率与白种人群体明显不同。
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