胰岛素受体基因酪氨酸激酶结构域的单链构象多态性分析：在南非黑人和白人受试者中检测到的多态性
SSCP analysis of the tyrosine kinase domain of the insulin receptor gene: polymorphisms detected in South African black and white subjects.
作者信息
Panz V R, Ruff P, Joffe B I, Kedda M A, Seftel H C
机构信息
Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa.
出版信息
Hum Genet. 1996 Apr;97(4):438-40. doi: 10.1007/BF02267063.
The frequency of DNA polymorphisms in the tyrosine kinase domain (exons 17-21) of the insulin receptor gene was assessed in 30 black and 30 white South Africans, using single-stranded conformation polymorphism and direct sequencing analysis. A comparison of the frequencies of the normal versus the combined polymorphic alleles, found only in exon 17, showed a significant difference between black and white groups (P = 0.037).
运用单链构象多态性分析和直接测序分析，对30名南非黑人和30名南非白人胰岛素受体基因酪氨酸激酶结构域（外显子17 - 21）的DNA多态性频率进行了评估。仅在外显子17中发现的正常等位基因与组合多态性等位基因频率比较显示，黑人群体和白人群体之间存在显著差异（P = 0.037）。
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