Arozal Wawaimuli, Louisa Melva, Soetikno Vivian
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Front Cardiovasc Med. 2020 May 6;7:82. doi: 10.3389/fcvm.2020.00082. eCollection 2020.
Increased prevalence of metabolic syndrome (MetS) in the world influences quality of health in all respective countries, including Indonesia. Data from Indonesian Family Life Survey reported in 2019 showed that the prevalence of MetS in Indonesia currently is 21.66%, estimated with the provincial incidence ranging up to 50%; additionally, the most common components of MetS discovered in Indonesia were poor high-density lipoprotein (HDL) cholesterol and hypertension. Management treatment of MetS involves a combination of lifestyle changes and pharmacological interventions to decrease cerebrovascular disease. Various natural substances have been shown to govern any cardiovascular or metabolic disorders through different mechanisms, such as triggering anti-inflammation, lipid profile correction, sensitization of insulin reception, or blood glucose control. In Indonesia, the utilization of natural compounds is part of the nation's culture. The community widely uses them; even though in general, their effectiveness and safety have not been thoroughly assessed by rigorous clinical trials. Scientific evidence suggested that cinnamon, mangosteen, and curcumin, as well as their derived components possess a broad spectrum of pharmacological activity. In this review, an enormous potential of cinnamon, mangosteen, and curcumin, which originated and are commonly used in Indonesia, could be treated against MetS, such as diabetes, hyperlipidemia, hypertension, and obesity. The findings suggested that cinnamon, mangosteen, curcumin and their derivatives may reflect areas of promise in the management of MetS.
全球代谢综合征（MetS）患病率的上升影响着包括印度尼西亚在内的各个国家的健康质量。2019年报告的印度尼西亚家庭生活调查数据显示，印度尼西亚目前MetS的患病率为21.66%，据估计各省份的发病率高达50%；此外，在印度尼西亚发现的MetS最常见组成部分是高密度脂蛋白（HDL）胆固醇水平低和高血压。MetS的管理治疗包括生活方式改变和药物干预相结合，以降低脑血管疾病风险。各种天然物质已被证明可通过不同机制控制任何心血管或代谢紊乱，如引发抗炎、纠正血脂谱、使胰岛素受体敏感或控制血糖。在印度尼西亚，天然化合物的使用是该国文化的一部分。社区广泛使用它们；尽管总体而言，其有效性和安全性尚未通过严格的临床试验进行全面评估。科学证据表明，肉桂、山竹和姜黄素及其衍生成分具有广泛的药理活性。在本综述中，原产于印度尼西亚且常用的肉桂、山竹和姜黄素具有巨大潜力，可用于治疗MetS，如糖尿病、高脂血症、高血压和肥胖症。研究结果表明，肉桂、山竹、姜黄素及其衍生物可能在MetS的管理方面展现出前景。
