Keator David B, Phelan Michael J, Taylor Lisa, Doran Eric, Krinsky-McHale Sharon, Price Julie, Ballard Erin E, Kreisl William C, Hom Christy, Nguyen Dana, Pulsifer Margaret, Lai Florence, Rosas Diana H, Brickman Adam M, Schupf Nicole, Yassa Michael A, Silverman Wayne, Lott Ira T
Department of Psychiatry and Human Behavior University of California Irvine California.
Institute for Memory Impairments and Neurological Disorders, UC Irvine California.
Alzheimers Dement (Amst). 2020 Apr 17;12(1):e12013. doi: 10.1002/dad2.12013. eCollection 2020.
Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI-DS) and test these hypotheses using cross-sectional and longitudinal data.
18F-AV-45 (florbetapir) positron emission tomography (PET) data were collected to analyze amyloid burden in 58 participants clinically classified as cognitively stable (CS) or MCI-DS and 12 longitudinal CS participants.
The study confirmed our hypotheses of increased amyloid in inferior parietal, lateral occipital, and superior frontal regions as the main effects differentiating MCI-DS from the CS groups. The largest annualized amyloid increases in longitudinal CS data were in the rostral middle frontal, superior frontal, superior/middle temporal, and posterior cingulate cortices.
This study helps us to understand amyloid in the MCI-DS transitional state between cognitively stable aging and frank dementia in DS. The spatial distribution of Aβ may be a reliable indicator of MCI-DS in DS.
唐氏综合征（DS）与患痴呆症的风险较高相关。我们假设特定脑区的β淀粉样蛋白（Aβ）可区分唐氏综合征中的轻度认知障碍（MCI-DS），并使用横断面和纵向数据来检验这些假设。
收集18F-AV-45（氟代贝他吡）正电子发射断层扫描（PET）数据，以分析58名临床分类为认知稳定（CS）或MCI-DS的参与者以及12名纵向CS参与者的淀粉样蛋白负荷。
该研究证实了我们的假设，即顶下叶、枕外侧叶和额上叶区域的淀粉样蛋白增加是区分MCI-DS组和CS组的主要因素。纵向CS数据中年化淀粉样蛋白增加最大的区域是额中回前部、额上叶、颞上/中叶和后扣带回皮质。
本研究有助于我们了解MCI-DS在唐氏综合征中从认知稳定衰老到明显痴呆的过渡状态下的淀粉样蛋白情况。Aβ的空间分布可能是唐氏综合征中MCI-DS的可靠指标。
