Department of Urology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Korea.
Data Science Team, Hanmi Pharmaceutical. Co. Ltd., Seoul, Korea.
World J Urol. 2021 Mar;39(3):877-882. doi: 10.1007/s00345-020-03257-1. Epub 2020 May 20.
Colder seasons can aggravate lower urinary tract symptoms, especially an overactive bladder (OAB). This aspect has been extensively studied in men and rarely in women. We investigated whether colder seasons influence OAB-drug prescription rates (OAB-DPRs) in women.
Women aged > 18 years were selected from the Korean Health Insurance Review and Assessment Service-National Patient Sample data between 2012 and 2016. OAB-DPR was calculated according to age and seasonal groups. The prescription rates in summer (June, July, and August) and winter (January, February, and December) months were compared. Sub-analysis was performed according to age group.
In total, 3,061,343 adult women were included. The overall OAB-DPR was 3.75% (114,940/3,061,343). Overall OAB-DPRs in summer and winter were 1.41% (43,090/3,061,343) and 1.54% (47,038/3,061,343), respectively (p < 0.001). Seasonal variations in OAB-DPRs differed by age group (p < 0.001): OAB-DPRs were significantly lower in winter than in summer months in women aged < 50 years (odds ratio 0.942; 95% confidence interval 0.918-0.967; p < 0.001), but significantly higher in winter than in summer months in women aged ≥ 50 years (odds ratio 1.153; 95% confidence interval 1.135-1.171; p < 0.001).
In this study, a correlation was noted between OAB-DPR and seasons. OAB-DPRs were higher in the summer in women aged < 50 years and higher in the winter in women aged ≥ 50 years. Our findings suggest that female hormonal status may be involved in the contradictory effect of seasons on OAB symptoms.
寒冷季节会加重下尿路症状，尤其是膀胱过度活动症（OAB）。这方面在男性中已得到广泛研究，但在女性中很少研究。我们调查了寒冷季节是否会影响女性的 OAB 药物处方率（OAB-DPR）。
我们从 2012 年至 2016 年的韩国健康保险审查和评估服务-国家患者样本数据中选择了年龄大于 18 岁的女性。根据年龄和季节组计算 OAB-DPR。比较了夏季（6、7、8 月）和冬季（1、2、12 月）的处方率。根据年龄组进行了亚组分析。
共有 3061343 名成年女性入组。总体 OAB-DPR 为 3.75%（114940/3061343）。夏季和冬季的总体 OAB-DPR 分别为 1.41%（43090/3061343）和 1.54%（47038/3061343）（p<0.001）。OAB-DPR 随年龄组的季节性变化不同（p<0.001）：<50 岁的女性冬季 OAB-DPR 明显低于夏季（比值比 0.942；95%置信区间 0.918-0.967；p<0.001），但≥50 岁的女性冬季 OAB-DPR 明显高于夏季（比值比 1.153；95%置信区间 1.135-1.171；p<0.001）。
在这项研究中，OAB-DPR 与季节之间存在相关性。<50 岁女性夏季 OAB-DPR 较高，≥50 岁女性冬季 OAB-DPR 较高。我们的研究结果表明，女性激素状态可能与季节对 OAB 症状的相反影响有关。
