Kim Jong Won, Ahn Hyun Kyu, Ko Jongcheol, Lee Dongu, Ha Jee Soo, Kim Jae Hwan, Park So Jeong, Cho Kang Su
Department of Urology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Data Science Team, Hanmi Pharmaceutical. Co. Ltd., Seoul, Korea.
Int Neurourol J. 2020 Sep;24(3):278-285. doi: 10.5213/inj.2040030.015. Epub 2020 Sep 30.
Overactive bladder (OAB) symptoms might be affected by weather, but only a few clinical studies have investigated this issue. We investigated seasonal variations in OAB-drug prescription rate (DPR) in men using nationwide claims data in Korea.
A total of 2,824,140 men aged over 18 years were included from the Health Insurance Review and Assessment service - National Patient Sample data between 2012 and 2016. Depending on the monthly average temperature, the seasons were divided into 3 groups, namely, hot (June, July, August, and September), intermediate (April, May, October, and November), and cold (January, February, March, and December) seasons. OAB-DPR was estimated using the claims data, and differences in its rate were examined among the 3 seasonal groups.
The overall OAB-DPR was 1.97% (55,574 of 2,824,140). The OAB-DPR were 0.38%, 0.63%, 0.92%, 1.74%, 4.18%, 7.55%, and 9.69% in the age groups of under 30, 30s, 40s, 50s, 60s, 70s, and over 80 years, respectively; thus, the prescription rate increased with age (P<0.001), with a steeper increase after 60 years of age. OAB-DPR was 1.02% in the hot season, 1.19% in the intermediate season, and 1.27% in the cold season, with significant differences among the 3 seasonal groups (P<0.001). These seasonal variations persisted in the subgroup analysis in each age decade (P<0.001).
OAB-DPR varied with seasons and was significantly higher in the cold season than in the hot season, suggesting that cold weather may affect development and aggravation of OAB symptoms in men.
膀胱过度活动症（OAB）症状可能受天气影响，但仅有少数临床研究调查过此问题。我们利用韩国全国性理赔数据，对男性OAB药物处方率（DPR）的季节性变化进行了调查。
纳入2012年至2016年间健康保险审查与评估服务机构-全国患者样本数据中2824140名18岁以上男性。根据月平均气温，季节分为3组，即炎热季（6月、7月、8月和9月）、过渡季（4月、5月、10月和11月）和寒冷季（1月、2月、3月和12月）。利用理赔数据估算OAB-DPR，并比较3个季节组的发生率差异。
总体OAB-DPR为1.97%（2824140人中55574人）。30岁以下、30多岁、40多岁、50多岁、60多岁、70多岁和80岁以上年龄组的OAB-DPR分别为0.38%、0.63%、0.92%、1.74%、4.18%、7.55%和9.69%；因此，处方率随年龄增加而升高（P<0.001），60岁以后升高更明显。炎热季OAB-DPR为1.02%，过渡季为1.19%，寒冷季为1.27%，3个季节组间差异有统计学意义（P<0.001）。各年龄十年的亚组分析中，这些季节性变化依然存在（P<0.001）。
OAB-DPR随季节变化，寒冷季显著高于炎热季，提示寒冷天气可能影响男性OAB症状的发生和加重。
