Melbourne Dental School, University of Melbourne, Carlton, Victoria, Australia.
Centre for Medicine Use and Safety, Monash University, Parkville, Victoria, Australia.
Br J Clin Pharmacol. 2021 Jan;87(1):152-162. doi: 10.1111/bcp.14373. Epub 2020 Jun 26.
Antibiotic resistance is a global public health problem. Around 55% of dental antibiotic prescribing is deemed inappropriate. The aim of this multimodal interventional pilot study was to assess the effect on prescribing of education and a dentally designed prescribing website.
Twenty-six dentists were recruited for the 12-week study using a pre-post design. Dentists self-recorded their prescribing of antibiotics, analgesics and anxiolytics for 6 weeks. After dentists were provided education and website access, they recorded their prescribing for a further 6 weeks. Four outcomes were measured comparing the prescribing before and after the intervention: (i) the number of inappropriate indications for which antibiotics were prescribed; (ii) the number of prescriptions; (iii) accuracy of the prescriptions according to the Australian therapeutic guidelines; and (iv) the confidence of practitioners towards the prescribing website. Participants were interviewed for feedback.
There was a substantial reduction of 44.6% in the number of inappropriate indications for which antibiotics were prescribed after the intervention and a decrease of 40.5% in the total number of antibiotics. Paracetamol with codeine substantially reduced by 56.8%. For the 3 most commonly prescribed antibiotics (amoxicillin, phenoxymethylpenicillin and metronidazole), there was the improvement in the accuracy of the prescriptions ranging from 0-64.7 to 74.2-100%.
This pilot study showed the intervention of targeted education and the prescribing tool was effective in improving dental prescribing, knowledge and confidence of practitioners, as well as providing an effective antibiotic stewardship tool. This context-specific intervention shows substantial promise for implementation into dental practice.
抗生素耐药性是一个全球性的公共卫生问题。大约 55%的牙科抗生素处方被认为是不适当的。本多模态干预性试点研究的目的是评估教育和专门为牙科设计的处方网站对处方的影响。
采用前后设计,招募了 26 名牙医参加为期 12 周的研究。牙医自行记录了他们在 6 周内开抗生素、镇痛药和解热药的情况。在为牙医提供教育和网站访问权限后,他们又记录了他们在接下来的 6 周内的处方情况。通过比较干预前后的四个结果来衡量处方:(i)抗生素开具的不适当适应症数量;(ii)处方数量;(iii)根据澳大利亚治疗指南的处方准确性;以及(iv)从业者对处方网站的信心。对参与者进行了访谈以获取反馈。
干预后,抗生素开具的不适当适应症数量减少了 44.6%,抗生素总用量减少了 40.5%。对乙酰氨基酚与可待因的用量减少了 56.8%。对于最常开的三种抗生素(阿莫西林、苯氧甲基青霉素和甲硝唑),处方的准确性从 0-64.7%提高到 74.2-100%。
这项试点研究表明,有针对性的教育和处方工具的干预措施在改善牙科处方、提高从业者的知识和信心以及提供有效的抗生素管理工具方面是有效的。这种针对具体情况的干预措施在牙科实践中的实施具有很大的潜力。