Department of Pharmacy, Zhejiang Hospital, Hangzhou, Zhejiang, China.
Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Nutr Cancer. 2021;73(4):652-661. doi: 10.1080/01635581.2020.1767166. Epub 2020 May 21.
Nonalcoholic fatty liver disease (NAFLD) and obesity are becoming increasingly common globally and characteristic as gut microbiota disturbance. Supplement of probiotics is considered as a promising strategy for NAFLD and obesity treatment. However, this effect varied from each other in clinical trials. We proposed that combination with a prebiotic substrate may improve the effects of probiotics. Thus, in this study, we investigated the separated and combined effects of and resveratrol (RSV) against obesity and NAFLD. NAFLD was caused by high-fat diet (HFD) feeding for 8 weeks. HFD-treated mice were orally treated with (1 × 10 CFU/mouse/day), RSV (100 mg/kg/day), and both of them from the fifth week. HFD feeding caused obesity and NAFLD as indicated by significantly increased body and liver weights, liver steatosis, elevated serum transaminases and lipid profiles, increased inflammation and imbalanced redox status. Based on these physical and biochemical parameters, inflammatory and antioxidant markers, individual administration of and RSV alleviated obesity and NAFLD, while coadministration of both products further enhanced the efficacy. These data suggested that combined prebiotic RSV and probiotic would be a potential candidate or adjuvant for the treatment of obesity and NAFLD.
非酒精性脂肪性肝病（NAFLD）和肥胖症在全球范围内变得越来越普遍，其特征是肠道微生物群失调。益生菌补充剂被认为是治疗 NAFLD 和肥胖症的一种有前途的策略。然而，这种效果在临床试验中彼此不同。我们提出，与益生元底物结合可能会提高益生菌的效果。因此，在这项研究中，我们研究了 和白藜芦醇（RSV）对肥胖症和非酒精性脂肪性肝病的单独和联合作用。非酒精性脂肪性肝病是通过高脂肪饮食（HFD）喂养 8 周引起的。HFD 处理的小鼠从第 5 周开始口服给予 （1×10 CFU/只/天）、RSV（100mg/kg/天）或两者的混合物。HFD 喂养导致肥胖症和非酒精性脂肪性肝病，表现为体重和肝脏重量显著增加、肝脂肪变性、血清转氨酶和脂质谱升高、炎症增加和氧化还原状态失衡。基于这些生理和生化参数、炎症和抗氧化标志物，单独给予 和 RSV 可减轻肥胖症和非酒精性脂肪性肝病，而两者联合使用则进一步增强了疗效。这些数据表明，联合使用益生元 RSV 和益生菌 可能是非酒精性脂肪性肝病和肥胖症的潜在候选药物或辅助药物。
