Suthiwong Jittra, Sribuhom Thurdpong, Wongphakham Paweena, Senawong Thanaset, Yenjai Chavi
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Department of Science and Mathematics, Faculty of Industry and Technology, Rajamangala University of Technology Isan, Sakon Nakhon, Thailand.
Nat Prod Res. 2021 Dec;35(23):4930-4938. doi: 10.1080/14786419.2020.1749616. Epub 2020 May 21.
Four new acylphloroglucinol derivatives , , and were isolated from the fruits of , and in addition, thirteen known compounds were also discovered. All compounds were evaluated for cytotoxicity against HeLa and HCT116 cell lines, as well as normal cells (Vero cells). Compound showed cytotoxicity against HeLa and HCT116 cell lines with IC values of 4.53 ± 0.05 and 4.53 ± 0.16 μg/mL, respectively, and showed less activity against normal cells (IC = 13.38 ± 0.75 μg/mL). Compound may be useful for the development of anticancer agents. It was found that decanoyl side chain may be necessary for the cytotoxicity. The chemical structures of all isolated compounds were elucidated using spectroscopic methods including 1 D-NMR, 2 D-NMR, MS and IR data.
从[植物名称]果实中分离出四种新的酰基间苯三酚衍生物，即[化合物名称1]、[化合物名称2]、[化合物名称3]和[化合物名称4]，此外，还发现了13种已知化合物。对所有化合物进行了针对HeLa和HCT116细胞系以及正常细胞（Vero细胞）的细胞毒性评估。化合物[化合物名称1]对HeLa和HCT116细胞系显示出细胞毒性，IC值分别为4.53±0.05和4.53±0.16μg/mL，对正常细胞的活性较低（IC = 13.38±0.75μg/mL）。化合物[化合物名称1]可能有助于抗癌药物的开发。发现癸酰侧链可能是细胞毒性所必需的。使用包括1D-NMR、2D-NMR、MS和IR数据在内的光谱方法阐明了所有分离化合物的化学结构。
