Cytotoxicity of acylphloroglucinol derivatives from the fruits of .

Four new acylphloroglucinol derivatives , , and were isolated from the fruits of , and in addition, thirteen known compounds were also discovered. All compounds were evaluated for cytotoxicity against HeLa and HCT116 cell lines, as well as normal cells (Vero cells). Compound showed cytotoxicity against HeLa and HCT116 cell lines with IC values of 4.53 ± 0.05 and 4.53 ± 0.16 μg/mL, respectively, and showed less activity against normal cells (IC = 13.38 ± 0.75 μg/mL). Compound may be useful for the development of anticancer agents. It was found that decanoyl side chain may be necessary for the cytotoxicity. The chemical structures of all isolated compounds were elucidated using spectroscopic methods including 1 D-NMR, 2 D-NMR, MS and IR data.