和的果皮中的 Atalantums H-K 及其细胞毒性。
Atalantums H-K from the peels of and their cytotoxicity.
机构信息
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
出版信息
Nat Prod Res. 2020 Aug;34(15):2124-2130. doi: 10.1080/14786419.2019.1576042. Epub 2019 Feb 27.
Four new benzoyltyramines, atalantums H-K (-) and seven known compounds were isolated from the peels of . All compounds were tested for cytotoxicity against HeLa, HCT116 and MCF-7 cell lines, as well as normal cells (Vero cells). Compound showed cytotoxicity against HeLa, HCT116 and MCF-7 cell lines with IC values ranging from 16-25 μg/mL but was inactive against Vero cells. Compound also showed interesting results as compound with IC values ranging from 15-18 μg/mL and an IC value of 80.20 μg/mL against Vero cells. This means compounds and can be used as lead compounds for anticancer agents.
从 中皮分离得到四个新的苯甲酰基酪氨酸，atalantums H-K（-）和七个已知化合物。所有化合物均进行了细胞毒性测试，针对 HeLa、HCT116 和 MCF-7 细胞系以及正常细胞（Vero 细胞）。化合物 对 HeLa、HCT116 和 MCF-7 细胞系表现出细胞毒性，IC 值范围为 16-25 μg/mL，但对 Vero 细胞无活性。化合物 也表现出有趣的结果，与化合物 相比，IC 值范围为 15-18 μg/mL，对 Vero 细胞的 IC 值为 80.20 μg/mL。这意味着化合物 和 可以用作抗癌药物的先导化合物。
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