Lacroix B, Didier E, Grenier J F
INSERM Unité 61-Service de Chirurgie B, Hôpital Civil, Strasbourg.
Int J Vitam Nutr Res. 1988;58(4):407-13.
In order to analyze the possible role of pantothenic acid (PA) and ascorbic acid (AA) in wound healing processes, the effects of these vitamins upon the growth of fibroblasts, obtained from human fetal skin or foreskin, were studied. Cell proliferation, protein synthesis and protein release were evaluated. The rate of cell growth remained identical when PA or AA were added to the culture medium. PA increased the basal incorporation of 14C proline into precipitated material while AA did not modify this action. However, when cultures were incubated with PA and AA, the release of intracellular protein into the culture medium increased. These results suggest that the combined use of these two vitamins might be of interest in postsurgical therapy and in wound healing.
为了分析泛酸（PA）和抗坏血酸（AA）在伤口愈合过程中可能发挥的作用，研究了这些维生素对从人胎儿皮肤或包皮中获取的成纤维细胞生长的影响。对细胞增殖、蛋白质合成和蛋白质释放进行了评估。当将PA或AA添加到培养基中时，细胞生长速率保持不变。PA增加了14C脯氨酸向沉淀物质中的基础掺入量，而AA没有改变这种作用。然而，当培养物与PA和AA一起孵育时，细胞内蛋白质向培养基中的释放增加。这些结果表明，这两种维生素的联合使用可能在术后治疗和伤口愈合中具有意义。
