Vaxman F, Olender S, Lambert A, Nisand G, Aprahamian M, Bruch J F, Didier E, Volkmar P, Grenier J F
INSERM U 61, Hospices Civils, Strasbourg, France.
Eur Surg Res. 1995;27(3):158-66. doi: 10.1159/000129395.
This study aimed at testing human skin wound healing improvement by a 21-day supplementation of 1.0 g ascorbic acid (AA) and 0.2 g pantothenic acid (PA). 49 patients undergoing surgery for tattoos, by the successive resections procedure, entered a double-blind, prospective and randomized study. Tests performed on both skin and scars determined: hydroxyproline concentrations, number of fibroblasts, trace element contents and mechanical properties. In the 18 supplemented patients, it was shown that in skin (day 8) Fe increased (p < 0.05) and Mn decreased (p < 0.05); in scars (day 21), Cu (p = 0.07) and Mn (p < 0.01) decreased, and Mg (p < 0.05) increased; the mechanical properties of scars in group A were significantly correlated to their contents in Fe, Cu and Zn, whereas no correlation was shown in group B. In blood, AA increased after surgery with supplementation, whereas it decreased in controls. Although no major improvement of the would healing process could be documented in this study, our results suggest that the benefit of AA and PA supplementation could be due to the variations of the trace elements, as they are correlated to mechanical properties of the scars.
本研究旨在通过连续21天补充1.0克抗坏血酸（AA）和0.2克泛酸（PA）来测试其对人类皮肤伤口愈合的改善作用。49名接受纹身手术的患者，采用连续切除程序，进入一项双盲、前瞻性和随机研究。对皮肤和疤痕进行的测试确定了：羟脯氨酸浓度、成纤维细胞数量、微量元素含量和机械性能。在18名补充营养素的患者中，结果显示在皮肤（第8天）中，铁含量增加（p<0.05），锰含量降低（p<0.05）；在疤痕（第21天）中，铜（p=0.07）和锰（p<0.01）含量降低，镁含量增加（p<0.05）；A组疤痕的机械性能与其铁、铜和锌的含量显著相关，而B组未显示相关性。在血液中，补充营养素后手术后AA含量增加，而对照组则降低。虽然本研究中未记录到伤口愈合过程有重大改善，但我们的结果表明，补充AA和PA的益处可能归因于微量元素的变化，因为它们与疤痕的机械性能相关。
