Department of Animal Morphology and Physiology, FCAVJ-UNESP-São Paulo State University, Jaboticabal, Brazil.
Department of Pediatrics, Centre de recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.
J Appl Physiol (1985). 2020 Jun 1;128(6):1533-1538. doi: 10.1152/japplphysiol.00335.2020. Epub 2020 May 21.
In recent months, the coronavirus disease 2019 (COVID-19) pandemic has sent many countries into crisis. Studies have shown that this virus causes worse outcomes and a higher mortality in men than in women. It has been recognized that sex can affect the immune response to a pathogenic agent, as well as the susceptibility for some respiratory diseases. These different responses in males and females may be related to the actions of sex hormones. Angiotensin-converting enzyme 2 (ACE2) acts as the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. The expression of ACE2 is influenced by sex hormones; therefore, we discuss in this article that this could be one of the reasons why COVID-19 is more prevalent in men than in women.
最近几个月，2019 冠状病毒病（COVID-19）大流行使许多国家陷入危机。研究表明，这种病毒在男性中的预后更差，死亡率更高。人们已经认识到，性别会影响对病原体的免疫反应，以及一些呼吸道疾病的易感性。男性和女性之间的这些不同反应可能与性激素的作用有关。血管紧张素转换酶 2（ACE2）是导致 COVID-19 的严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的受体。ACE2 的表达受性激素影响；因此，我们在本文中讨论了这可能是 COVID-19 在男性中比女性更普遍的原因之一。
