Department of Psychiatry, Faculty of Medicine, Tekirdağ Namık Kemal University, Süleymanpaşa, 59100, Tekirdağ, Turkey.
Department of Biochemistry, Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
Eur Arch Psychiatry Clin Neurosci. 2023 Sep;273(6):1339-1347. doi: 10.1007/s00406-022-01514-5. Epub 2022 Nov 10.
Coronavirus disease 2019 (COVID-19) affects numerous systems of the body during the illness, and there have been long-lasting effects. BDNF plays an important role in synaptic plasticity and synaptic communication. According to the inclusion and exclusion criteria, 54 patients who had COVID-19 infection participated in this study. Thirty-six age-, sex-, body mass index (BMI)-, education level- and smoking status-matched healthy controls were included in the present study. All participants were individually administered the Stroop test and Visual Aural Digit Span Test Form B (VADS-B). Serum BDNF levels were measured by ELISA. Stroop test word reading spontaneous correction number and reading time, word color saying wrong number, spontaneous correction number and reading time, box color speaking spontaneous correction number and reading time, Stroop interference and speed factor duration were significantly higher in the COVID-19 group than in the control group. All scores of the VADS-B test were found to be significantly lower in the COVID-19 group. The mean serum BDNF levels were found to be 10.9 ± 6.9 ng/ml in the COVID-19 group and 12.8 ± 6.4 ng/ml in the healthy control group. Two-way ANOVA showed that the serum mean BDNF level was significantly lower in the COVID-19 group than in the control group. Gender had a significant effect on BDNF levels (F = 12.21; p = 0.008). The present study is the first to demonstrate the association between the role of serum BDNF and cognitive decline in patients with COVID-19 infection. Additionally, there is a significant role of male gender in terms of lower BDNF level and cognitive decline.
新型冠状病毒疾病 2019（COVID-19）在疾病过程中会影响身体的众多系统，并且存在持久的影响。BDNF 在突触可塑性和突触通讯中发挥着重要作用。根据纳入和排除标准，本研究纳入了 54 名患有 COVID-19 感染的患者。本研究纳入了 36 名年龄、性别、体重指数（BMI）、教育水平和吸烟状况相匹配的健康对照者。所有参与者均单独接受斯特鲁普测试和视觉听觉数字跨度测试 B 型（VADS-B）。通过 ELISA 测量血清 BDNF 水平。COVID-19 组的斯特鲁普测试词阅读自发校正数和阅读时间、词色说错数、自发校正数和阅读时间、盒色说自发校正数和阅读时间、斯特鲁普干扰和速度因子持续时间明显高于对照组。COVID-19 组的 VADS-B 测试所有分数均明显低于对照组。COVID-19 组的平均血清 BDNF 水平为 10.9±6.9ng/ml，健康对照组为 12.8±6.4ng/ml。双向方差分析显示 COVID-19 组的血清平均 BDNF 水平明显低于对照组。性别对 BDNF 水平有显著影响（F=12.21；p=0.008）。本研究首次证明了 COVID-19 感染患者血清 BDNF 与认知能力下降之间的关联。此外，男性性别在 BDNF 水平和认知能力下降方面具有显著作用。
