Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States of America.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States of America; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.
Fitoterapia. 2020 Jul;144:104612. doi: 10.1016/j.fitote.2020.104612. Epub 2020 May 11.
Four new unusual 19-nor-pimarane-type diterpenes were isolated from the tuber of Icacina trichantha (Icacinaceae, Oliv.). The structures were elucidated based on spectroscopic and HRMS analysis. The absolute configurations were determined by electronic circular dichroism. All four compounds are structural analogues of icacinol and humirianthol, but do not demonstrate the same cytotoxic activity. A plausible biogenetic pathway is proposed.
从山桐子（山桐子科，山桐子科）的块茎中分离得到了四种新的非寻常的 19-降-贝壳杉烷型二萜。根据光谱和高分辨质谱分析确定了结构。通过电子圆二色性确定了绝对构型。这四种化合物都是 icacinol 和 humirianthol 的结构类似物，但没有表现出相同的细胞毒性活性。提出了一个合理的生物发生途径。
