Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.
J Nat Prod. 2021 Apr 23;84(4):949-955. doi: 10.1021/acs.jnatprod.9b01131. Epub 2021 Mar 26.
Eleven pimarane-type diterpenoids were isolated from the tubers of , including three new compounds, icacinlactone M (), icacinlactone H 2--β-d-glucopyranoside (), and icacinlactone N 3--β-d-glucopyranoside (), together with an artifact of acrenol (). Among the known structures, icacinlactone A (), icacinlactone B (), icacinlactone H (), 12-hydroxyicacinlactone A (), 14α-methoxyhumirianthol (), and annonalide () are reported from for the first time, whereas icacinol () has previously been found in this plant. Icacinol, 14α-methoxyhumirianthol, and annonalide displayed moderate cytotoxic activity in a panel of human cancer cell lines.
从滇桐的块茎中分离得到 11 个新的匹马烷型二萜，包括 3 个新化合物，即伊卡宁内酯 M（）、伊卡宁内酯 H2--β-d-吡喃葡萄糖苷（）和伊卡宁内酯 N3--β-d-吡喃葡萄糖苷（），以及一个阿瑞醇的副产物（）。在已知结构中，伊卡宁内酯 A（）、伊卡宁内酯 B（）、伊卡宁内酯 H（）、12-羟基伊卡宁内酯 A（）、14α-甲氧基胡米醇（）和安诺内酯（）首次从该植物中分离得到，而伊卡宁（）以前曾在该植物中发现。伊卡宁、14α-甲氧基胡米醇和安诺内酯在一组人类癌细胞系中表现出中等的细胞毒性活性。
