Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, College of Pharmacy , Nanjing University of Chinese Medicine , Nanjing 210023 , China.
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60612 , United States.
J Agric Food Chem. 2018 Aug 1;66(30):7859-7872. doi: 10.1021/acs.jafc.8b02602. Epub 2018 Jul 24.
Momilactones are allelochemicals in rice and moss defense. Momilactone-like compounds are therefore considered important secondary metabolites for plant defense. They may serve as promising lead compounds for crop-friendly herbicides as well as antifungal and antibacterial agents. Many of these substances possess potent cytotoxicity property against cancer cell lines as well. The present paper is the first review on these versatile molecules, focusing on the structure, biological activity, chemical synthesis, and biosynthesis of the naturally occurring momilactone-like molecules reported from 1973 to 2017.
毛豆素是水稻和苔藓防御中的化感物质。因此，毛豆素类似物被认为是植物防御的重要次生代谢物。它们可以作为有前途的作物友好型除草剂以及抗真菌和抗细菌剂的先导化合物。许多这些物质对癌细胞系也具有很强的细胞毒性。本文是第一篇关于这些多功能分子的综述，重点介绍了 1973 年至 2017 年报道的天然毛豆素类似物的结构、生物活性、化学合成和生物合成。
