Rider Cynthia V, Vallant Molly, Blystone Chad, Waidyanatha Suramya, South Natalie L, Xie Guanhua, Turner Katie
Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Toxicol Lett. 2020 May 11;330:159-166. doi: 10.1016/j.toxlet.2020.05.005.
N-Butylbenzenesulfonamide (NBBS) is a plasticizer and emerging contaminant that has been detected in a wide array of environmental samples. There are very little toxicity data available with which to evaluate potential risk from exposure to NBBS or other structurally-related sulfonamide plasticizers. To address this knowledge gap, NBBS was selected by the National Toxicology Program for evaluation. The current short-term pre- and post-natal (perinatal) study aims to provide preliminary toxicity and gestational transfer data for NBBS. NBBS was administered via dosed feed at concentrations of 0, 625, 1250, 2500, 5000, and 10,000 ppm to time-mated Sprague Dawley (Hsd:Sprague Dawley SD®) rats from gestation day (GD) 6 through postnatal day (PND) 28. The high concentration of 10,000 ppm NBBS was overtly toxic to dams, and the group was removed on GD 17-18. Exposure to NBBS resulted in lower maternal weights during the gestational period in the 5000 and 10,000 ppm groups as compared to control weights. Dams also displayed lower weights in the lactational period, which resolved to control levels by PND 28. NBBS exposure did not affect pregnancy or littering parameters in F0 dams. However, pup survival was lower in the 5000 ppm group, and pup weights were dose-responsively lower than control pup weights with the difference expanding over the postnatal period. The lowest observed effect level (LOEL) based on significantly lower body weights was 5000 ppm NBBS for F0 dams and 2500 ppm NBBS for F1 pups. Preliminary data for NBBS levels indicated that the chemical was transferred from dams to offspring during the gestational period.
N-丁基苯磺酰胺（NBBS）是一种增塑剂，也是一种新出现的污染物，已在大量环境样品中被检测到。目前几乎没有毒性数据可用于评估接触NBBS或其他结构相关磺酰胺增塑剂的潜在风险。为填补这一知识空白，美国国家毒理学计划选择了NBBS进行评估。当前的短期产前和产后（围产期）研究旨在提供NBBS的初步毒性和孕期转移数据。从妊娠第6天（GD）到出生后第28天（PND），通过喂食给药，以0、625、1250、2500、5000和10000 ppm的浓度将NBBS给予定时交配的斯普拉格·道利（Hsd:Sprague Dawley SD®）大鼠。10000 ppm的高浓度NBBS对母鼠具有明显毒性，该组在GD 17 - 18被剔除。与对照组体重相比，5000和10000 ppm组在妊娠期接触NBBS导致母鼠体重降低。母鼠在哺乳期体重也较低，但到PND 28时恢复到对照水平。接触NBBS对F0代母鼠的妊娠或产仔参数没有影响。然而，5000 ppm组幼崽存活率较低，幼崽体重呈剂量依赖性低于对照幼崽体重，且差异在出生后阶段不断扩大。基于明显较低体重的最低观察到有害作用水平（LOEL），F0代母鼠为5000 ppm NBBS，F1代幼崽为2500 ppm NBBS。NBBS水平的初步数据表明，该化学物质在妊娠期从母鼠转移到了后代。
