丹酚酸 A 通过抑制 NF-κB 和 p38/MAPK 通路发挥抗炎和抗关节炎作用。

Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways.

机构信息

The Second People's Hospital of Nantong, Nantong, Jiangsu, People's Republic of China.

出版信息

Drug Des Devel Ther. 2020 May 8;14:1771-1778. doi: 10.2147/DDDT.S235857. eCollection 2020.

INTRODUCTION

Osteoarthritis (OA), a chronic joint disease, combines with massive inflammation and plays a vital role in cartilage degeneration. The main strategy in clinic is controlling inflammation, thereby treating osteoarthritis. Salvianolic acid A (SAA) is a type of phenolic acid, derived from a traditional chinese herbal medicine Danshen that is extensively used clinically.

METHODS AND RESULTS

We observed the anti-inflammatory and antiarthritic effects of SAA in IL-1β-stimulated cells. We found that SAA evidently decreased the expression of mainly inflammatory factors, exerted the remarkable effects of anti-inflammation and anti-arthritis. Furthermore, SAA inhibited the expression of Matrix metalloproteinases (MMP1, MMP13), and ADAMTS-5 and raised the synthesis of collagen II and aggrecan. Additionally, the results indicated that SAA gave rise to the effects by down-regulation of NF-κB and p38/MAPK pathways.

DISCUSSION

Our study demonstrates that SAA may be a promising anti-inflammatory for the treatment of OA in clinic.

简介

骨关节炎（OA）是一种慢性关节疾病，伴有大量炎症，在软骨退化中起着至关重要的作用。临床上的主要策略是控制炎症，从而治疗骨关节炎。丹酚酸 A（SAA）是一种酚酸，来源于临床广泛应用的传统中药丹参。

方法和结果

我们观察了 SAA 在 IL-1β 刺激的细胞中的抗炎和抗关节炎作用。我们发现 SAA 明显降低了主要炎症因子的表达，具有显著的抗炎和抗关节炎作用。此外，SAA 抑制了基质金属蛋白酶（MMP1、MMP13）和 ADAMTS-5 的表达，提高了胶原 II 和聚集蛋白聚糖的合成。此外，结果表明 SAA 通过下调 NF-κB 和 p38/MAPK 通路发挥作用。