Guerrero Tania P, Fickel Jörns, Benhaiem Sarah, Weyrich Alexandra
Department Evolutionary Genetics, Leibniz-Institute for Zoo and Wildlife Research (IZW), Alfred-Kowalke-Str. 17, Berlin, D-10315, Germany.
Faculty of Environment and Natural Resources, Albert Ludwig University of Freiburg, Tennenbacher Str. 4, Freiburg, D-79085, Germany.
Curr Zool. 2020 Jun;66(3):307-319. doi: 10.1093/cz/zoaa005. Epub 2020 Feb 25.
Social epigenomics is a new field of research that studies how the social environment shapes the epigenome and how in turn the epigenome modulates behavior. We focus on describing known gene-environment interactions (GEIs) and epigenetic mechanisms in different mammalian social systems. To illustrate how epigenetic mechanisms integrate GEIs, we highlight examples where epigenetic mechanisms are associated with social behaviors and with their maintenance through neuroendocrine, locomotor, and metabolic responses. We discuss future research trajectories and open questions for the emerging field of social epigenomics in nonmodel and naturally occurring social systems. Finally, we outline the technological advances that aid the study of epigenetic mechanisms in the establishment of GEIs and vice versa.
社会表观基因组学是一个新的研究领域，它研究社会环境如何塑造表观基因组，以及表观基因组如何反过来调节行为。我们专注于描述不同哺乳动物社会系统中已知的基因-环境相互作用（GEIs）和表观遗传机制。为了说明表观遗传机制如何整合基因-环境相互作用，我们重点介绍了一些例子，其中表观遗传机制与社会行为及其通过神经内分泌、运动和代谢反应的维持相关。我们讨论了非模式生物和自然发生的社会系统中社会表观基因组学这一新兴领域未来的研究方向和悬而未决的问题。最后，我们概述了有助于研究基因-环境相互作用建立过程中表观遗传机制的技术进展，反之亦然。
