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社会表观基因组学与癌症中的挑战与机遇

Challenges and Opportunities in Social Epigenomics and Cancer.

作者信息

Banaudha Krishna, Kumar Vineet, Verma Mukesh

机构信息

Department of Biochemistry and Molecular Biology, School of Medicine and Public Health, George Washington University, Washington, DC, USA.

Department of Pharmacology, National University of Singapore, Singapore, Singapore.

出版信息

Methods Mol Biol. 2018;1856:233-243. doi: 10.1007/978-1-4939-8751-1_13.

Abstract

Social epigenomics is an area of science that evaluates why and how different social factors and processes affect different components of the epigenome. As it happens with most of the new areas in science, social epigenetics being a relatively new area, only limited progress has been made. However, the potential of implicating social epigenomics in improving health and health related policies is tremendous. Epidemiologic studies evaluating social, behavior, family, and environmental factors have helped understand social inequality and develop the area of social epigenomics. Most of the information in social epidemiology has been gathered from genetic studies. Now the time has come that we may apply similar approaches in social epigenomics because technologies of determining methylation, histone, and noncoding RNA profiling are well developed. The focus of this chapter is to understand the role of epigenetic regulation in social experiences at various stages in life due to altered function of genes and affecting health in populations with different races/ethnicity. Here we discuss the current challenges and opportunities in the field.

摘要

社会表观基因组学是一个科学领域,它评估不同社会因素和过程为何以及如何影响表观基因组的不同组成部分。正如科学领域中的大多数新领域一样,社会表观遗传学作为一个相对较新的领域,目前仅取得了有限的进展。然而,将社会表观基因组学应用于改善健康及与健康相关政策的潜力是巨大的。评估社会、行为、家庭和环境因素的流行病学研究有助于理解社会不平等现象,并推动社会表观基因组学领域的发展。社会流行病学中的大多数信息都是从基因研究中收集而来的。现在,由于确定甲基化、组蛋白和非编码RNA谱的技术已经成熟,我们或许可以在社会表观基因组学中应用类似的方法了。本章的重点是了解表观遗传调控在生命各个阶段的社会经历中的作用,这些经历因基因功能改变而产生,并影响不同种族/民族人群的健康。在此,我们将讨论该领域当前面临的挑战和机遇。

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