Lanzhou University, Lanzhou, 730000, China.
Hebei Provincial Meteorological Bureau, Shijiazhuang, 050021, China.
Int J Biometeorol. 2020 Jul;64(7):1039-1050. doi: 10.1007/s00484-019-01788-w. Epub 2020 May 21.
This study aimed to investigate the effects of heat waves and ozone on hypertensive rats. Heat wave and ozone pollution were simulated on the Shanghai Meteorological and Environmental Animal Exposure System. Eighteen hypertensive rats were randomly divided into a control group, an ozone group, and a heat wave plus ozone group. The experimental groups were transferred to the exposure system for exposure to the ozone and heat wave plus ozone. After exposure, blood samples were collected from the abdominal aorta, and the hearts were harvested in all groups. The concentrations of inflammatory factors, vasomotion factors, cardiovascular risk factors, oxidative stress and thrombosis factors and heat stress factors in heart tissue were measured in each rat. Ozone exposure and heat wave plus ozone exposure increased the levels of inflammatory factors, thrombosis factors, vasomotion factors and cardiovascular risk factors, except for HDL-C, which was reduced. Moreover, experimental exposure increased the heat stress factors and oxidative stress, except for SOD, which was decreased. These data demonstrated that both ozone exposure and heat wave plus ozone exposure could adversely affect hypertensive rats, and that heat wave may enhance the toxic effect of ozone exposure.
本研究旨在探讨热浪和臭氧对高血压大鼠的影响。在上海气象环境动物暴露系统上模拟了热浪和臭氧污染。将 18 只高血压大鼠随机分为对照组、臭氧组和热浪加臭氧组。实验组被转移到暴露系统中，分别暴露于臭氧和热浪加臭氧中。暴露后，从腹主动脉采集血样，并从所有组中采集心脏。测量每组大鼠心脏组织中炎症因子、血管运动因子、心血管危险因素、氧化应激和血栓形成因素以及热应激因素的浓度。臭氧暴露和热浪加臭氧暴露增加了炎症因子、血栓形成因子、血管运动因子和心血管危险因素的水平，除了高密度脂蛋白胆固醇（HDL-C）降低。此外，实验暴露增加了热应激因素和氧化应激，除了超氧化物歧化酶（SOD）降低。这些数据表明，臭氧暴露和热浪加臭氧暴露都可能对高血压大鼠产生不良影响，并且热浪可能会增强臭氧暴露的毒性作用。
