发育关键期暴露于大麻：神经精神疾病相关的表观遗传和分子途径。
Cannabis Exposure During Critical Windows of Development: Epigenetic and Molecular Pathways Implicated in Neuropsychiatric Disease.
机构信息
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Center for Computational Biology, University of California, Berkeley, CA, USA.
出版信息
Curr Environ Health Rep. 2020 Sep;7(3):325-342. doi: 10.1007/s40572-020-00275-4.
Abstract
PURPOSE OF REVIEW
Cannabis exposure during critical windows of development may have intergenerational physiological consequences disrupting epigenetic programming and marks. This review examines the literature relating to pre-gestational and prenatal cannabinoid exposure and its effect on genes and molecular pathways related to the development of psychiatric disease.
RECENT FINDINGS
Developmental cannabis exposure alters epigenetic processes with functional gene consequences. These include potentially heritable alterations in genes and molecular pathways critical for brain development and associated with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia, addiction, and other psychiatric diseases. Cannabis consumption and mental health illness in adolescents and young adults are increasing in the United States (U.S.), and recent studies suggest that cannabis consumption during critical periods of brain development could contribute to mental health illness through epigenetic mechanisms. These findings warrant future studies and consideration by regulators and health communicators.
摘要
目的综述
在发育关键窗口期接触大麻可能会产生代际生理后果，破坏表观遗传编程和标记。本综述探讨了与孕前和产前大麻接触及其对与精神疾病发展相关的基因和分子途径的影响有关的文献。
最近的发现
发育性大麻暴露改变了表观遗传过程，具有功能性基因后果。其中包括对大脑发育关键基因和分子途径的潜在可遗传改变，这些基因和分子途径与自闭症谱系障碍 (ASD)、注意力缺陷多动障碍 (ADHD)、精神分裂症、成瘾和其他精神疾病有关。在美国，青少年和年轻人的大麻消费和精神健康疾病正在增加，最近的研究表明，在大脑发育的关键时期吸食大麻可能会通过表观遗传机制导致精神健康疾病。这些发现值得未来的研究以及监管机构和卫生传播者的考虑。
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