Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province, Chengdu, 611130, China.
The College of Animal Science and Veterinary Medicine, Henan Agricultural University, Henan Province, Zhengzhou, 450002, China.
Food Chem Toxicol. 2020 Aug;142:111438. doi: 10.1016/j.fct.2020.111438. Epub 2020 May 20.
Trichothecenes are a class of toxic secondary metabolites produced by filamentous fungi such as Fusarium, which pose a threat to human and animal health. Among them, T-2 toxin and deoxynivalenol (DON) have attracted the most attention because of their extensive pollution and strong toxicity. Accumulated studies have found that an increase of reactive oxygen species (ROS) during oxidative stress produces a wide range of secondary consequences by modifying cell signaling proteins, such as DNA RNA damage, inflammatory damage, cell cycle arrest, and apoptosis. Although there has been a comprehensive review of antioxidant agents against trichothecenes, there is no systematic summary of the mechanism of trichothecenes inducing ROS production and then regulating downstream signaling molecules of cells to produce the corresponding effects. Therefore, from the perspective of ROS regulation of downstream signaling pathways, this review mainly explores the mechanisms by which ROS, as trichothecenes' handy weapon, affect an organism. It may provide more ideas and new targets for studies of antagonizing the toxicity of trichothecenes from the aspect of antioxidation.
三哩醇是一类由镰刀菌等丝状真菌产生的有毒次生代谢物，对人类和动物健康构成威胁。其中，T-2 毒素和脱氧雪腐镰刀菌烯醇（DON）由于其广泛的污染和强烈的毒性而引起了最多的关注。已有的大量研究发现，氧化应激过程中活性氧（ROS）的增加通过修饰细胞信号蛋白（如 DNA 和 RNA 损伤、炎症损伤、细胞周期停滞和细胞凋亡）产生广泛的次级后果。尽管已经对抗氧化剂对抗三哩醇进行了全面的综述，但没有系统地总结三哩醇诱导 ROS 产生，然后调节细胞下游信号分子产生相应效应的机制。因此，本综述从 ROS 调节下游信号通路的角度，主要探讨了 ROS 作为三哩醇的得力武器，影响生物体的机制。这可能为从抗氧化角度研究拮抗三哩醇毒性提供更多的思路和新的靶点。
