Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, 10065, USA.
Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA, 10065.
Int J Surg. 2020 Jul;79:76-83. doi: 10.1016/j.ijsu.2020.05.036. Epub 2020 May 19.
Coronary artery bypass grafting (CABG) is one of the most commonly performed cardiac procedures in the United States (US) and Europe. In the US, perioperative morbidity and mortality related to CABG are below 5%. One of the most significant complications following CABG, however, is perioperative myocardial infarction (PMI). Cardiac biomarkers, intra- and post-operative echocardiography, and electrocardiography are routinely used to monitor for evidence of PMI. In this review, we seek to summarize how each of these modalities is used in the clinical setting to differentiate PMI from expected procedure-related changes, and how these findings impact patients' outcomes. We conclude that while no perfect diagnostic test for the detection of clinically meaningful PMI exists, using a combination of existing modalities with knowledge of expected post-procedure changes allows for early and reliable detection. Future development is needed to create more sensitive and specific modalities for the detection of PMI in patients undergoing CABG.
冠状动脉旁路移植术(CABG)是美国和欧洲最常进行的心脏手术之一。在美国,CABG 相关的围手术期发病率和死亡率低于 5%。然而,CABG 后最严重的并发症之一是围手术期心肌梗死(PMI)。心脏生物标志物、术中及术后超声心动图和心电图通常用于监测 PMI 的证据。在这篇综述中,我们旨在总结这些方法在临床环境中如何用于区分 PMI 与预期的与手术相关的变化,以及这些发现如何影响患者的结局。我们的结论是,虽然目前还没有用于检测有临床意义的 PMI 的完美诊断测试,但结合使用现有的方法并了解预期的术后变化,可以实现早期、可靠的检测。未来需要开发更敏感和特异的方法来检测 CABG 患者的 PMI。