Pierce W M, Nerland D E
Department of Pharmacology and Toxicology, University of Louisville, School of Medicine, Kentucky 40292.
J Anal Toxicol. 1988 Nov-Dec;12(6):344-7. doi: 10.1093/jat/12.6.344.
Phenol and related compounds are toxic agents to which humans are exposed. Analysis of phenolic compounds may be used as an index of exposure. In this report a method for analysis of phenol, phenylglucuronide, phenylsulfate, and related mono- and dihydroxybenzenes as their propanoate esters by gas chromatography/mass spectrometry is presented. The use of this derivatization technique increases the sensitivity of the analysis by improving chromatographic performance and introducing a traceable "reporter" group into the analyte. This method has also been adapted, by using selected ion monitoring (SIM), to the quantitative analysis of phenol.
苯酚及相关化合物是人类可能接触到的有毒物质。酚类化合物的分析可用作接触指标。本报告介绍了一种通过气相色谱/质谱法分析苯酚、苯基葡糖醛酸苷、苯基硫酸盐以及相关单羟基和二羟基苯的丙酸酯的方法。这种衍生化技术的使用通过改善色谱性能并将可溯源的“报告”基团引入分析物来提高分析的灵敏度。该方法还通过使用选择离子监测（SIM）来进行苯酚的定量分析。
