Gebicka Lidia
Faculty of Chemistry, Institute of Applied Radiation Chemistry, Lodz University of Technology (TUL), Lodz, Poland.
J Inorg Biochem. 2020 Jul;208:111095. doi: 10.1016/j.jinorgbio.2020.111095. Epub 2020 May 3.
Proteins containing heme groups perform a variety of important functions in living organisms. The heme groups are involved in catalyzing oxidation/reduction reactions, in electron transfer, and in binding small molecules, like oxygen or nitric oxide. Flavonoids, low molecular weight plant polyphenols, are ubiquitous components of human diet. They are also components of many plant extracts used in herbal medicine as well as of food supplements. Due to their relatively low reduction potential, flavonoids are prone to oxidation. This paper provides a review of redox reactions of various heme proteins, including catalase, some peroxidases, cytochrome P450, cytochrome c, myoglobin, and hemoglobin with flavonoids. Potential biological significance of these reactions is discussed, in particular when flavonoids are delivered to the body at pharmacological doses.
含有血红素基团的蛋白质在生物体内发挥着多种重要功能。血红素基团参与催化氧化/还原反应、电子转移以及结合小分子，如氧气或一氧化氮。黄酮类化合物是低分子量的植物多酚，是人类饮食中普遍存在的成分。它们也是许多用于草药的植物提取物以及食品补充剂的成分。由于其相对较低的还原电位，黄酮类化合物易于氧化。本文综述了各种血红素蛋白与黄酮类化合物的氧化还原反应，包括过氧化氢酶、一些过氧化物酶、细胞色素P450、细胞色素c、肌红蛋白和血红蛋白。讨论了这些反应潜在的生物学意义，特别是当黄酮类化合物以药理剂量进入人体时。
