Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, CZ-121 08 Prague, Czech Republic.
BIOCEV, First Faculty of Medicine, Charles University, Prague, CZ-252 50 Vestec, Czech Republic.
Int J Mol Sci. 2021 Jan 11;22(2):646. doi: 10.3390/ijms22020646.
Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.
类黄酮是常见的植物天然产物，能够抑制与 ROS 相关的损伤并减轻氧化应激。其参与这一现象的关键机制之一是螯合过渡金属离子。从生理学角度来看，铁是最重要的过渡金属，因为它在生物体内含量丰富，并且广泛参与氧化还原过程。类黄酮的化学、药物和生物学特性会受到其与过渡金属离子（主要是铁）相互作用的显著影响。在这篇综述中，我们解释了各种类黄酮结构与 Fe(II)和 Fe(III)离子的相互作用，并批判性地讨论了螯合离子对类黄酮生化特性的影响。此外，还包括其铁配合物的特定生物学效应，例如抑制含铁酶。
