Obstet Gynecol. 2020 Jun;135(6):e261-e274. doi: 10.1097/AOG.0000000000003893.
Both thyrotoxicosis and hypothyroidism are associated with adverse pregnancy outcomes. There also is concern about the effect of overt maternal thyroid disease on fetal development. In addition, medications that affect the maternal thyroid gland can cross the placenta and affect the fetal thyroid gland. This document reviews the thyroid-related pathophysiologic changes that occur during pregnancy and the effects of overt and subclinical maternal thyroid disease on maternal and fetal outcomes. This Practice Bulletin has been updated with information on the diagnosis and the management of thyroid disease in pregnant women and includes a new clinical algorithm on management of thyroid disease in pregnancy.
无论是甲状腺功能亢进症还是甲状腺功能减退症，都会对妊娠结局产生不良影响。此外，人们还担心显性母体甲状腺疾病对胎儿发育的影响。另外，影响母体甲状腺的药物可以穿过胎盘并影响胎儿的甲状腺。本文回顾了妊娠期间发生的与甲状腺相关的病理生理变化，以及显性和亚临床母体甲状腺疾病对母婴结局的影响。本实践公告已更新了关于孕妇甲状腺疾病的诊断和管理的信息，并包括一个新的关于妊娠期甲状腺疾病管理的临床算法。
