中国西北地区人群线粒体和 Y 染色体分子标记的联合遗传分析。
Joint Genetic Analyses of Mitochondrial and Y-Chromosome Molecular Markers for a Population from Northwest China.
机构信息
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
出版信息
Genes (Basel). 2020 May 18;11(5):564. doi: 10.3390/genes11050564.
The genetic markers on mitochondria DNA (mtDNA) and Y-chromosome can be applied as a powerful tool in population genetics. We present a study to reveal the genetic background of Kyrgyz group, a Chinese ethnic group living in northwest China, and genetic polymorphisms of 60 loci on maternal inherited mtDNA and 24 loci on paternal inherited Y-chromosome short tandem repeats (Y-STRs) were investigated. The relationship between the two systems was tested, and the result indicated that they were statistically independent from each other. The genetic distances between Kyrgyz group and 11 reference populations for mtDNA, and 13 reference populations for Y-STRs were also calculated, respectively. The present results demonstrated that the Kyrgyz group was genetically closer to East Asian populations than European populations based on the mtDNA loci but the other way around for the Y-STRs. The genetic analyses could largely strengthen the understanding for the genetic background of the Kyrgyz group.
线粒体 DNA（mtDNA）和 Y 染色体上的遗传标记可用作群体遗传学中的有力工具。我们进行了一项研究，旨在揭示生活在中国西北部的中国少数民族之一——柯尔克孜族的遗传背景，并对母系遗传 mtDNA 的 60 个位点和父系遗传 Y 染色体短串联重复（Y-STRs）的 24 个位点的遗传多态性进行了调查。测试了这两个系统之间的关系，结果表明它们在统计学上是相互独立的。还分别计算了柯尔克孜族与 11 个 mtDNA 参考群体和 13 个 Y-STRs 参考群体之间的遗传距离。本研究结果表明，基于 mtDNA 基因座，柯尔克孜族在遗传上与东亚人群比与欧洲人群更接近，但 Y-STRs 则相反。遗传分析可以在很大程度上加强对柯尔克孜族遗传背景的了解。
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