McElroy Taylor, Allen Antiño R
Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Antioxidants (Basel). 2020 May 18;9(5):439. doi: 10.3390/antiox9050439.
Oxidative stress is considered one of the possible mechanisms behind chemobrain or the cognitive dysfunction persistent after chemotherapy treatment. Breast cancer patients have reported chemobrain symptoms since the 1990s. In this present bibliometric review, we employed the VOSviewer tool to describe the existing landscape on literature concerning oxidative stress, breast cancer chemotherapies, and chemobrain. As of 2019, 8799 papers were listed in the Web of Science database, with more than 900 papers published each year. As expected, terms relating to oxidative stress, mitochondria, breast cancer, and antioxidants have occurred very often in the literature throughout the years. In recent years, there has been an increase in the occurrence of terms related to nanomedicine. Only within the last decade do the keywords 'brain', 'blood-brain barrier', and 'central nervous system' appear, reflecting an increased interest in chemobrain. China has become the most prolific producer of oxidative stress and chemotherapy related papers in the last decade followed by the USA and India. In conclusion, the subject of oxidative stress as a mechanism behind chemotherapies' toxicities is an active area of research.
氧化应激被认为是化疗脑或化疗治疗后持续存在的认知功能障碍背后的可能机制之一。自20世纪90年代以来，乳腺癌患者就报告了化疗脑症状。在本次文献计量学综述中，我们使用VOSviewer工具来描述有关氧化应激、乳腺癌化疗和化疗脑的现有文献状况。截至2019年，科学网数据库中列出了8799篇论文，每年发表的论文超过900篇。正如预期的那样，多年来，与氧化应激、线粒体、乳腺癌和抗氧化剂相关的术语在文献中频繁出现。近年来，与纳米医学相关的术语出现频率有所增加。仅在过去十年中，“大脑”、“血脑屏障”和“中枢神经系统”等关键词才出现，这反映出对化疗脑的兴趣日益浓厚。在过去十年中，中国已成为氧化应激和化疗相关论文产量最高的国家，其次是美国和印度。总之，氧化应激作为化疗毒性背后机制的研究是一个活跃的领域。
