Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Shanghai, 201318, China.
Bio-X Institutes, Shanghai Jiaotong University, Shanghai, 200030, China.
J Mol Neurosci. 2022 Sep;72(9):1977-1989. doi: 10.1007/s12031-022-02052-4. Epub 2022 Jul 21.
Mild cognitive impairment (MCI) is a pathological stage between normal cognitive aging and dementia. The blood-brain barrier (BBB) breakdown is emerging as an early biomarker of MCI. This study aimed to visually analyze the literatures related to MCI caused by BBB dysfunction in recent 20 years, systematically identify collaboration networks, track research trends, highlight current hot spots, and predict future frontiers in this field. The related literatures published from 2000 to 2021 were obtained from the Web of Science with the search term "mild cognitive impairment and (blood-brain barrier or neurovascular unit or neurovascular coupling)". VOSviewer software was used to present knowledge map, CiteSpace software was used to extract literature information and make tables, including the top most influential countries, authors, institutions, periodicals, keywords, and references. A total of 333 literatures were used for visual analysis. After 2013, the literatures in the field of BBB dysfunction-induced MCI showed an increased trend in terms of year of publication and quantity of material, with more than 40 publications published each year. USA, England, China, and Sweden cooperated closely. In terms of institutions, Harvard Med Sch ranked first in the number of papers published, followed by Mstricht Univ and Univ Washington. In terms of journals, three of the top five co-cited journals belonged to USA, the other two journals were Neurobiol Aging and J Alzheimers DIS, which were from England and Netherlands respectively. A total of 1752 authors were identified, with Abhay P Sagare the most published and Zlokovic BV the most cited. Keyword emergence detection analysis showed that inflammation, oxidative stress, and memory were new research hot spot in this field. Overall, the research on BBB dysfunction-induced MCI is booming. In the future, cooperation and communication between different countries and institutions should be strengthened.
轻度认知障碍（MCI）是正常认知老化和痴呆之间的病理阶段。血脑屏障（BBB）破坏作为 MCI 的早期生物标志物正在出现。本研究旨在对近 20 年来与 BBB 功能障碍引起的 MCI 相关的文献进行可视化分析，系统地识别合作网络，跟踪研究趋势，突出当前热点，并预测该领域的未来前沿。从 2000 年到 2021 年，从 Web of Science 中使用搜索词“轻度认知障碍和（血脑屏障或神经血管单元或神经血管耦合）”获得相关文献。VOSviewer 软件用于呈现知识图谱，CiteSpace 软件用于提取文献信息并制表，包括最具影响力的国家、作者、机构、期刊、关键词和参考文献。共使用 333 篇文献进行可视化分析。2013 年后，BBB 功能障碍引起的 MCI 领域的文献在发表年份和文献数量方面均呈上升趋势，每年发表的文献超过 40 篇。美国、英国、中国和瑞典合作密切。在机构方面，哈佛医学院发表的论文数量排名第一，紧随其后的是马斯特里赫特大学和华盛顿大学。在期刊方面，排名前五的合著期刊中有三个来自美国，另外两个期刊分别是《神经生物学衰老》和《阿尔茨海默病杂志》，分别来自英国和荷兰。共确定了 1752 位作者，其中 Abhay P Sagare 发表的文章最多，Zlokovic BV 引用的文章最多。关键词出现检测分析表明，炎症、氧化应激和记忆是该领域的新研究热点。总的来说，对 BBB 功能障碍引起的 MCI 的研究正在蓬勃发展。未来，应加强不同国家和机构之间的合作与交流。
