Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children Health, Mofid Children's Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Complement Ther Med. 2020 May;50:102331. doi: 10.1016/j.ctim.2020.102331. Epub 2020 Feb 13.
Since, the main cause of death in Rheumatoid arthritis (RA) patients is the presence of type 2 diabetes, abnormal increase in blood lipids, blood pressure and obesity, the aim of this study was to assess the effects of Barberry on the anthropometric indices and metabolic profile in patients with RA.
present study was a double-blinded, placebo-controlled randomized clinical trial.
70 active RA patients were randomly allocated into intervention or placebo group INTERVENTION: Participants received 6 capsules of 500 mg barberry extract or placebo for 3 months.
Serum levels of fasting blood sugar (FBS), triglyceride (TG), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C), systolic and diastolic blood pressure and anthropometric factors were assessed at baseline and at the end of the trial.
The results of intervention on 62 patients showed that weight, BMI, and conicity index increased in both groups, but this was significant only in the placebo group (p < 0.001). Waist and hip circumference were decreased in the intervention group and increased significantly in the placebo group (p < 0.001). Body fat percent (p = 0.04), LDL-C (p = 0.05) and SBP (p = 0.02) significantly were decreased in the intervention group. The results showed a significant decrease in body fat percent (p = 0.05), hip circumference (p < 0.001), FBS (p = 0.03) and HDL-C (p = 0.03) in the intervention group compared to the placebo.
Overall, the results of this study demonstrated that the extract of Berberis Integerrima had beneficial effects on metabolic profile and anthropometric indices in RA patients.
类风湿关节炎（RA）患者的主要死亡原因是 2 型糖尿病、血脂异常、血压升高和肥胖的存在，因此本研究旨在评估小檗碱对 RA 患者人体测量指标和代谢谱的影响。
本研究为双盲、安慰剂对照随机临床试验。
70 例活动性 RA 患者随机分为干预组或安慰剂组。
参与者接受 6 粒 500mg 小檗碱提取物或安慰剂，持续 3 个月。
在基线和试验结束时评估空腹血糖（FBS）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）、收缩压和舒张压以及人体测量因素的血清水平。
对 62 例患者的干预结果表明，两组体重、BMI 和肥胖指数均增加，但仅安慰剂组显著增加（p < 0.001）。干预组腰围和臀围减小，安慰剂组显著增加（p < 0.001）。干预组体脂百分比（p = 0.04）、LDL-C（p = 0.05）和 SBP（p = 0.02）显著降低。与安慰剂组相比，干预组体脂百分比（p = 0.05）、臀围（p < 0.001）、FBS（p = 0.03）和 HDL-C（p = 0.03）显著降低。
总的来说，本研究结果表明，贯叶连翘提取物对 RA 患者的代谢谱和人体测量指标有有益的影响。
