Department of Pathology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH (Society for Hematopathology Representative).
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Association for Molecular Pathology Representative).
Am J Clin Pathol. 2020 Jul 7;154(2):149-177. doi: 10.1093/ajcp/aqaa038.
At a discussion on molecular/cytogenetic education for hematopathology fellows at the 2018 Society for Hematopathology Program Directors Meeting, consensus was that fellows should understand basic principles and indications for and limitations of molecular/cytogenetic testing used in routine practice. Fellows should also be adept at integrating results of such testing for rendering a final diagnosis. To aid these consensus goals, representatives from the Society for Hematopathology and the Association for Molecular Pathology formed a working group to devise a molecular/cytogenetic curriculum for hematopathology fellow education.
The curriculum includes a primer on cytogenetics and molecular techniques. The bulk of the curriculum reviews the molecular pathology of individual malignant hematologic disorders, with applicable molecular/cytogenetic testing for each and following the 2017 World Health Organization classification of hematologic neoplasms. Benign hematologic disorders and bone marrow failure syndromes are also discussed briefly. Extensive tables are used to summarize genetics of individual disorders and appropriate methodologies.
This curriculum provides an overview of the current understanding of the molecular biology of hematologic disorders and appropriate ancillary testing for their evaluation. The curriculum may be used by program directors for training hematopathology fellows or by practicing hematopathologists.
在 2018 年血液病理学计划主任会议的分子/细胞遗传学教育讨论会上，与会者达成共识，即学员应了解在常规实践中使用的分子/细胞遗传学检测的基本原理、适应证和局限性。学员还应熟练掌握此类检测结果，以做出最终诊断。为了帮助实现这些共识目标，来自血液病理学协会和分子病理学协会的代表成立了一个工作组，为血液病理学学员教育制定了分子/细胞遗传学课程。
该课程包括细胞遗传学和分子技术入门。课程的主要内容是复习单个恶性血液系统疾病的分子病理学，针对每种疾病都有相应的分子/细胞遗传学检测，并遵循 2017 年世界卫生组织血液肿瘤分类。还简要讨论了良性血液系统疾病和骨髓衰竭综合征。大量表格用于总结各个疾病的遗传学和适当的方法学。
本课程概述了当前对血液系统疾病分子生物学的理解，以及对其评估的适当辅助检测。课程主任可以使用本课程培训血液病理学学员，也可以供执业血液病理学家使用。
