Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
School of Public Health, Department of Epidemiology, Boston University, Boston, Massachusetts, USA.
Int J Cancer. 2020 Nov 15;147(10):2772-2779. doi: 10.1002/ijc.33109. Epub 2020 Jun 18.
Direct comparisons of the incidence and survival of cutaneous vs mucocutaneous genital squamous cell carcinomas (SCCs) are lacking even though they may bring important insights. We aimed to compare incidence rates and survival of cutaneous and mucocutaneous genital SCCs head-to-head, using the same source population, cancer registry methodology and statistical methods in a population of predominantly white Caucasian descent. Using data (2007-2015) from the population-based cancer registry of North Rhine-Westphalia, (population of 18 million people), we estimated age-specific and age-standardized (old European standard) incidence rates and age-standardized relative 5-year survival of SCC with the period approach for the period 2012 to 2015. Overall, 83 650 SCC cases were registered. The age-standardized incidence rates (per 100 000 person-years) of cutaneous SCCs were 36.5 (SE 0.17) and 17.0 (SE 0.11) among men and women, respectively, with corresponding rates for mucocutaneous genital skin, 1.3 (SE 0.03) and 4.5 (SE 0.06) for men and women, respectively. In all age groups, incidence rates of mucocutaneous genital SCCs were higher in women than men. Men had higher cutaneous SCC incidence at all nongenital subsites than women, with the exception of the lower extremities. Five-year relative survival was considerably lower for mucocutaneous genital SCCs (men: 71%, women: 75%), especially of the scrotal skin (67%) and labia majora (62%) than for SCC of nongenital skin (men: 93%, women: 97%). Given their relatively high incidence together with a lower survival probability, future studies are warranted to establish therapies for advanced mucocutaneous genital SCC, such as immune checkpoint inhibition.
直接比较皮肤与黏膜外生殖器鳞状细胞癌（SCC）的发病率和生存率尚缺乏相关研究，尽管这可能会带来重要的见解。我们旨在使用相同的源人群、癌症登记方法和统计方法，对头对头比较皮肤和黏膜外生殖器 SCC 的发病率和生存率，研究人群主要为白种高加索人。我们使用北莱茵-威斯特法伦州基于人群的癌症登记处（人口 1800 万）的数据（2007-2015 年），采用时期法估计 2012 年至 2015 年期间 SCC 的年龄特异性和年龄标准化（旧欧洲标准）发病率，以及标准化相对 5 年生存率。总体而言，共登记了 83050 例 SCC 病例。男性和女性皮肤 SCC 的年龄标准化发病率（每 10 万人年）分别为 36.5（SE 0.17）和 17.0（SE 0.11），相应的黏膜外生殖器皮肤 SCC 发病率分别为 1.3（SE 0.03）和 4.5（SE 0.06）。在所有年龄组中，女性的黏膜外生殖器 SCC 发病率均高于男性。除下肢外，所有非生殖器部位的男性 SCC 发病率均高于女性。黏膜外生殖器 SCC 的 5 年相对生存率明显较低（男性：71%，女性：75%），尤其是阴囊皮肤（67%）和大阴唇（62%）的生存率低于非生殖器皮肤 SCC（男性：93%，女性：97%）。鉴于黏膜外生殖器 SCC 的发病率相对较高，生存率较低，未来需要进一步研究为晚期黏膜外生殖器 SCC 建立治疗方法，例如免疫检查点抑制。
