Division of Dermatology, University of Florence, Florence, Italy.
Cancer Research "Attilia Pofferi" Foundation, Pistoia, Italy.
Br J Dermatol. 2019 Mar;180(3):565-573. doi: 10.1111/bjd.17321. Epub 2018 Dec 26.
Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs).
The aim of our study was to evaluate incidence and survival for cases of CACs and investigate their association with other skin neoplasms.
We conducted a population-based study. Data on incident cases of CACs were obtained from the Tuscany Cancer Registry between 1985 and 2010. In order to determine whether the occurrence of squamous cell carcinoma (SCC) among patients with CAC is higher or lower than expected in the general population, the standardized incidence ratio (SIR) was calculated.
A total of 242 patients with CAC were observed; the age-standardized incidence rate was 3·8 cases per million person-years. From 1997 to 2010 crude incidence rates increased by 159%. Age-specific incidence was higher in men over 80 years old than in women of the same age and younger individuals. Carcinomas of sweat gland origin prevailed; the most common histotype was porocarcinoma and the most frequently affected site was the head/neck. Overall, 88% of CACs were diagnosed at a localized stage. The 5-year overall survival and disease-specific survival rates were 59% [95% confidence interval (CI) 53-65] and 94% (95% CI 91-98), respectively. In the observation cohort, the number of SCCs was significantly higher than expected as the SIR was calculated to be 33·7 (P < 0·001).
Increasing incidence warrants awareness and early diagnosis of CACs. Increased SCC incidence among patients with these tumours highlights the relevance of careful skin examination and follow-up.
最近的研究表明，皮肤附属器癌（CAC）的发病率不断上升。
我们的研究旨在评估 CAC 病例的发病率和生存率，并研究其与其他皮肤肿瘤的关系。
我们进行了一项基于人群的研究。CAC 病例的数据来自托斯卡纳癌症登记处 1985 年至 2010 年的记录。为了确定 CAC 患者中鳞状细胞癌（SCC）的发生是否高于或低于普通人群的预期，我们计算了标准化发病比（SIR）。
共观察到 242 例 CAC 患者；年龄标准化发病率为 3.8 例/百万人年。1997 年至 2010 年粗发病率增加了 159%。80 岁以上男性的年龄特异性发病率高于同年龄组和年轻个体的女性。起源于汗腺的癌居多；最常见的组织学类型是汗孔癌，最常受累的部位是头颈部。总体而言，88%的 CAC 患者在局部阶段被诊断出来。5 年总生存率和疾病特异性生存率分别为 59%（95%CI 53-65）和 94%（95%CI 91-98）。在观察队列中，SCC 的数量明显高于预期，因为计算的 SIR 为 33.7（P<0.001）。
发病率的增加需要提高对 CAC 的认识并进行早期诊断。这些肿瘤患者中 SCC 发病率的增加突出了仔细的皮肤检查和随访的重要性。
