Department of Pharmacology Daejeon University College of Oriental Medicine, Daejeon, Korea.
University of Gachon Lee Gil Ya Cancer and Diabetes Institute, Incheon, Korea.
Curr Pharm Des. 2020;26(25):2971-2981. doi: 10.2174/1381612826666200523180301.
The stable gastric pentadecapeptide BPC 157 protects stomach cells, maintains gastric integrity against various noxious agents such as alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs), and exerts cytoprotection/ adaptive cytoprotection/organoprotection in other epithelia, that is, skin, liver, pancreas, heart, and brain. Especially BPC 157 counteracts gastric endothelial injury that precedes and induces damage to the gastric epithelium and generalizes "gastric endothelial protection" to protection of the endothelium of other vessels including thrombosis, prolonged bleeding, and thrombocytopenia. In this background, we put the importance of BPC 157 as a possible way of securing GI safety against NSAIDs-induced gastroenteropathy since still unmet medical needs to mitigate NSAIDs-induced cytotoxicity are urgent. Furthermore, gastrointestinal irritants such as physical or mental stress, NSAIDs administration, surfactants destroyer such as bile acids, alcohol can lead to leaky gut syndrome through increasing epithelial permeability. In this review article, we described the potential rescuing actions of BPC 157 against leaky gut syndrome after NSAIDs administration for the first time.
稳定的胃十五肽 BPC 157 能保护胃细胞，防止胃黏膜受到各种有害物质的侵害，如酒精、非甾体抗炎药（NSAIDs），并在其他上皮细胞（即皮肤、肝脏、胰腺、心脏和大脑）中发挥细胞保护/适应性细胞保护/器官保护作用。特别是 BPC 157 可以对抗胃内皮损伤，这种损伤先于并诱导胃上皮损伤，并将“胃内皮保护”推广到包括血栓形成、延长出血和血小板减少症在内的其他血管内皮保护。在此背景下，我们认为 BPC 157 作为一种确保 GI 安全的可能方法非常重要，因为减轻 NSAIDs 诱导的细胞毒性的未满足的医疗需求非常迫切。此外，物理或精神压力、NSAIDs 给药、表面活性剂破坏剂（如胆汁酸）、酒精等胃肠道刺激物可通过增加上皮通透性导致肠漏综合征。在这篇综述文章中，我们首次描述了 BPC 157 在 NSAIDs 给药后对抗肠漏综合征的潜在抢救作用。
