Bajramagic Salem, Sever Marko, Rasic Fran, Staresinic Mario, Skrtic Anita, Beketic Oreskovic Lidija, Oreskovic Ivana, Strbe Sanja, Loga Zec Svjetlana, Hrabar Josip, Coric Luka, Prenc Matea, Blagaic Vladimir, Brcic Klara, Boban Blagaic Alenka, Seiwerth Sven, Sikiric Predrag
Department of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Clinic of General and Abdominal Surgery, Clinical Center University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina.
Pharmaceuticals (Basel). 2024 Aug 17;17(8):1081. doi: 10.3390/ph17081081.
By introducing the healing of many distinctive anastomoses by BPC 157 therapy, this review practically deals with the concept of the resection and reconnection of the hollow parts of the gastrointestinal tract as one of the cornerstones of visceral surgery. In principle, the healing of quite distinctive anastomoses itself speaks for applied BPC 157 therapy, in particular, as a way in which the therapy of anastomoses can be successfully approached and carried out. Some of the anastomoses implicated were esophagogastric, colocolonic, jejunoileal, and ileoileal anastomoses, along with concomitant disturbances, such as esophagitis, sphincter dysfunction, failed intestinal adaptation, colitis, short bowel syndrome, major vessel occlusion, NO-system, and prostaglandins-system dysfunction, which were accordingly counteracted as well, and, finally, findings concerning other anastomoses healing (i.e., nerve and vessel). Moreover, the healing of fistulas, both external and internal, colocutaneous, gastrocutaneous, esophagocutaneous, duodenocutaneous, vesicovaginal, colovesical, and rectovaginal in rats, perceived as anastomoses made between two different tissues which are normally not connected, may also be indicative. This may be a particular reconnection of the parts of the gastrointestinal tract to re-establish adequate integrity depending on the tissue involved, given that both various intestinal anastomoses and various fistulas (intestinal and skin were accordingly healed simultaneously as the fistulas disappeared) were all healed.
通过介绍BPC 157疗法对多种独特吻合口的愈合作用，本综述实际上探讨了胃肠道中空部分的切除与重新连接这一概念，它是内脏外科的基石之一。原则上，相当独特的吻合口自身的愈合就表明了所应用的BPC 157疗法的有效性，特别是作为一种能够成功开展吻合口治疗的方法。其中涉及的一些吻合口包括食管胃吻合口、结肠结肠吻合口、空肠回肠吻合口和回肠回肠吻合口，以及伴随的紊乱情况，如食管炎、括约肌功能障碍、肠道适应性不良、结肠炎、短肠综合征、大血管闭塞、一氧化氮系统和前列腺素系统功能障碍，这些也都相应地得到了缓解，最后还有关于其他吻合口愈合（即神经和血管）方面的研究结果。此外，大鼠体内外部瘘、结肠皮肤瘘、胃皮肤瘘、食管皮肤瘘、十二指肠皮肤瘘、膀胱阴道瘘、结肠膀胱瘘和直肠阴道瘘的愈合，这些被视为通常不相连的两种不同组织之间形成的吻合口，也可能具有指示意义。鉴于各种肠吻合口和各种瘘（随着瘘消失，肠道和皮肤同时愈合）都实现了愈合，这可能是胃肠道各部分的一种特殊重新连接，以根据所涉及的组织重新建立足够的完整性。
